Melitracen; Uses, Dosage, Side Effects, Interactions

Melitracen; Uses, Dosage, Side Effects, Interactions

Melitracen is a tricyclic antidepressant respectively, for the treatment of depression and anxiety. In addition to single drug preparations, it is also available as Deanxit, a combination product containing both melitracen and flupentixol

Mechanism of action of Melitracen

Flupentixol inhibits dopamine-mediated effects by blocking postsynaptic dopamine receptors in the CNS. Melitracen is a TCA with anxiolytic properties. At low doses, it has to activate properties. It is also a bipolar thymoleptic.
Absorption: Flupentixol: Readily absorbed in the GI tract.
Distribution: Flupentixol: >95% bound to plasma proteins; widely distributed in the body and crosses the blood-brain barrier.
Metabolism: Flupentixol: Extensively hepatic metabolism.
Excretion: Flupentixol: Excreted in urine and feces in the form of many metabolites.

Indications of Melitracen

Contra-Indications of Melitracen

Dosage of Melitracen

  • Adult:1 – 2 tablet to be taken daily.


  • Adult: Initially, 25 mg bid-tid, gradually increased to 225 mg daily if necessary.
  • Elderly: Initially, 25 mg daily.

Side Effects of Melitracen

The most common 

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More common


Drug Interactions of Melitracen

Melitracen may interact with following drugs, supplements & may change the efficacy of drugs

Pregnancy & Lactation of Melitracen

FDA Pregnancy category‎ ‎C


This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately. Newborn babies who have been exposed to this medication in the last 3 months of pregnancy have experienced withdrawal symptoms after birth.

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This medication passes into breast milk. If you are a breastfeeding mother and are taking flupenthixol, it may affect your baby. Talk to your doctor about whether you should breastfeeding-feeding.






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