Flupentixol; Uses, Dosage, Side Effects, Interactions

Flupentixol; Uses, Dosage, Side Effects, Interactions

Flupentixol is an antipsychotic neuroleptic drug. It is a thioxanthene, and therefore closely related to the phenothiazines. Its primary use is as a long-acting injection given two or three weeks to people with schizophrenia who have a poor compliance with medication and suffer frequent relapses of illness. It is a D1 and D2 receptor antagonist.

Mechanism of Action of flupentixol

Flupenthixol is a thioxanthene antipsychotic. The mechanism of action of Flupenthixol is not completely understood. Flupenthixol is a powerful antagonist of both D1 and D2 dopamine receptors and an alpha-adrenergic receptor antagonist. Its antipsychotic activity is thought to be related to blocks postsynaptic dopamine receptors in the CNS.

Indications of flupentixol

Contra-Indications of Flupentixol

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Dosage of Flupentixol


  • As decanoate: Initially, 20 mg (1 ml of a 2% oily solution) is given as test dose. After at least 7 days and depending on the response, subsequent doses of 20-40 mg may be given at intervals of 2-4 wk.
  • Usual maintenance dose: 50 mg every 4 wk to 300 mg every 2 wk. Up to 400 mg wkly may be used in severe or resistant cases.
  • Initial dose: ¼ or ½ of the usual initial dose.

Depression with or without anxiety

  • Initially, 1 mg daily increased after 1 wk to 2 mg daily and then to a max of 3 mg daily, last dose should be given not later than 4 p.m.
  • Doses >2 mg should be given in 2 divided doses. Discontinue treatment if there is no improvement within 1 wk of using the max dose.
  • Initially, 0.5 mg daily increased after 1 wk to 1 mg daily with the last dose given not later than 4 p.m. Max: 2 mg daily in 2 divided doses.

Depression with psychoses

  • Initially, 3-9 mg bid, adjusted according to response. Max: 18 mg daily.
  • Initial dose: ¼ or ½ of the usual initial dose.

Side Effects of Flupentixol

The most common 

More common


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Drug Interactions of Flupentixol

Flupenthixol may interact with following drugs, supplements & may change the efficacy of drugs

Pregnancy & Lactation of Flupentixol

FDA Pregnancy category‎ ‎C


This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately. Newborn babies who have been exposed to this medication in the last 3 months of pregnancy have experienced withdrawal symptoms after birth.


This medication passes into breast milk. If you breastfeeding-feeding mother and are taking flupenthixol, it may affect your baby. Talk to your doctor about whether you should continue breastfeeding.

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