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Cefotiam; Indications, Contra indications, Dosage, Side effects, Interaction

Cefotiam Hydrochloride is the hydrochloride salt form of cefotiam, a second-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Mechanism of action of Cefotiam

The bactericidal activity of cefotiam results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefotiam is a third generation beta-lactam cephalosporin antibiotic. It has broad-spectrum activity against Gram-positive and Gram-negative bacteria. It does not have activity against Pseudomonas aeruginosa. Cefotiam works by inhibiting bacterial cell wall biosynthesis. Cefotiam is a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Indications of Cefotiam

For the treatment of infections caused by susceptible organisms.

For the treatment of serious infections caused by susceptible strains microorganisms.
Lower respiratory tract infections, including pneumonia and lung abscess,s
Urinary tract infections caused by Escherichia coli, Klebsiella species,
Intra-abdominal infections, including peritonitis and intra-abdominal abscess,
Gynecological infections, including endometritis, pelvic cellulitis, and pelvic inflammatory

Contra-Indications of Cefotiam

Liver problems
Interstitial nephritis
Subacute cutaneous lupus erythematosus
Systemic lupus erythematosus

Allergies cephalosporins & beta-lactams

Side Effects of Cefotiam

The most common

local tenderness or pain at the site of injection
skin color change, mild diarrhea
mild nausea
loss of appetite
vaginal discharge and itching
swelling of feet or legs
chest pain
constipation
cough
diarrhea or loose stools
difficulty with breathing
dizziness
heartburn

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More common

Abdominal or stomach pain, discomfort, or tenderness
chills or fever
difficulty with moving
a headache, severe and throbbing
joint or back pain
muscle aching or cramping
muscle pains or stiffness
chest pressure or squeezing pain in the chest
excessive sweating
feeling of heaviness, pain, warmth and/or swelling in a leg or in the pelvis
sudden tingling or coldness in an arm or leg
sudden slow or difficult speech
sudden drowsiness or need to sleep
fast breathing
sharp pain when taking a deep breath
fast or slow heartbeat
coughing up blood
rust colored urine
decreased amount of urine

Rare

Anxiety
change in vision
seizures
abnormal or fast heart rate
tremors
weight loss
chest pain or tightness
confusion
a cough
Agitation
arm, back, or jaw pain
blurred vision
chest pain or discomfort
convulsions
extra heartbeats
fainting
hallucinations
a headache
irritability
lightheadedness
mood or mental changes
muscle pain or cramps

Drug Interactions of Cefotiam

Cefotiam may interact with the following drugs, supplements, & may change the efficacy of drugs

aminoglycoside antibiotics (e.g., gentamicin, tobramycin)
probenecid
typhoid vaccine
cholera vaccine,
amoxicillin
Aspirin Low Strength (aspirin)
Diphenhydramine
Rosuvastatin
Duloxetine
Albuterol
Topiramate
Carbamazepine
Vitamin D3 (cholecalciferol)
Alprazolam
Cetirizine
Phenprocoumon
Picosulfuric acid
Warfarin

Pregnancy Catagory of Cefotiam

FDA Pregnancy Category B

Pregnancy

It is not known if cefotiam is safe for use by pregnant women. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

This medication may pass into breast milk. If you are a breastfeeding mother and are taking cefotiam it may affect your baby. Talk to your doctor about whether you should continue breastfeeding.It is not known if cefotiam is safe for children under 6 months of age.

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