Cefonicid; Uses, Indications, Dosage, Side Effects, Interaction

Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Indications of Cefonicid

For the treatment of serious infections caused by susceptible strains microorganisms.

• Lower respiratory tract infections, including pneumonia and lung abscess,s
•  Urinary tract infections caused by Escherichia coli, Klebsiella species,
• Intra-abdominal infections, including peritonitis and intra-abdominal abscess,
• Gynecological infections, including endometritis, pelvic cellulitis, and pelvic inflammatory disease caused
• Bacterial Infections
• Bloodstream Infections
• Bone and Joint Infections
• Aspiration Pneumonia Cesarean Section
• Bronchitis
• Tonsillitis
• Endometritis
• Flu caused by Influenza
• Infected animal bite
• Intra-Abdominal Infections
• Lower respiratory tract infection bacterial
• Peritonitis
• Pneumonia
• Skin and Subcutaneous Tissue Bacterial Infections
• Skin and skin structure infections caused by Staphylococcus aureus

Contra-Indications of  Cefonicid

• Clostridium difficile infection
• Decrease in the blood-clotting protein prothrombin
• Severe renal impairment
• Inadequate vitamin K
• Hemolytic anemia
• Liver problems
• Interstitial nephritis
• Subacute cutaneous lupus erythematosus
• Systemic lupus erythematosus
• Allergies cephalosporins & beta-lactams

Side Effects of Cefonicid

The most common

• local tenderness or pain at the site of injection
• skin color change, mild diarrhea
• mild nausea
• loss of appetite
• vaginal discharge and itching
• swelling of feet or legs
• chest pain
• constipation
• cough
• diarrhea or loose stools
• difficulty with breathing
• dizziness
• heartburn

More common

• Abdominal or stomach pain, discomfort, or tenderness
• chills or fever
• difficulty with moving
• headache, severe and throbbing
• joint or back pain
• muscle aching or cramping
• muscle pains or stiffness
• chest pressure or squeezing pain in chest
• excessive sweating
• feeling of heaviness, pain, warmth and/or swelling in a leg or in the pelvis
• sudden tingling or coldness in an arm or leg
• sudden slow or difficult speech
• sudden drowsiness or need to sleep
• fast breathing
• sharp pain when taking a deep breath
• fast or slow heartbeat
• coughing up blood
• rust colored urine
• decreased amount of urine

Rare

• Anxiety
• change in vision
• seizures
• abnormal or fast heart rate
• tremors
• weight loss
• chest pain or tightness
• confusion
• cough
• Agitation
• arm, back, or jaw pain
• blurred vision
• chest pain or discomfort
• convulsions
• extra heartbeats
• fainting
• hallucinations
• headache
• irritability
• lightheadedness
• mood or mental changes
• muscle pain or cramps

Drug Interactions of Cefonicid

Cefonicid may interact with the following drugs, supplements, & may change the efficacy of drugs

• aminoglycoside antibiotics (e.g., gentamicin, tobramycin)
• probenecid
• typhoid vaccine
• cholera vaccine,
• amoxicillin
• Aspirin Low Strength (aspirin) 
• Diphenhydramine
• Rosuvastatin
• Duloxetine
• Albuterol
• Topiramate
• Carbamazepine
• Vitamin B12 (cyanocobalamin)
• Vitamin D3 (cholecalciferol)
• Alprazolam
• Cetirizine
• Phenprocoumon
• Picosulfuric acid
• Warfarin

Pregnancy Catagory of Cefonicid

FDA Pregnancy Category  B

Pregnancy

It is not known if cefonicid is safe for use by pregnant women. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

This medication may pass into breast milk. If you are a breastfeeding mother and are taking cefonicid it may affect your baby. Talk to your doctor about whether you should continue breastfeeding. It is not known if cefonicid is safe for children under 6 months of age.

References