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Cefmenoxime; Indications/Uses, Dosage, Side effects, Interactions

Cefmenoxime is a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefmenoxime binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted. Cefmenoxime is a cephalosporin antibiotic that is administered intravenously or intramuscularly. It is active against most common gram-positive and gram-negative microorganisms, is a potent inhibitor of Enterobacteriaceae, and is highly resistant to hydrolysis by beta-lactamases. The drug has a high rate of efficacy in many types of infection and to date, no severe side effects have been noted.

Mechanism of Action of Cefmenoxime

The bactericidal activity of cefmenoxime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefmenoxime is stable in the presence of a variety of b-lactamases, including penicillinases and some cephalosporinases.

Cefmenoxime is a semisynthetic beta-lactam cephalosporin antibiotic with activity similar to that of cefotaxime. It has broad-spectrum activity against Gram-positive and Gram-negative bacteria.

Cefmenoxime is a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefmenoxime binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Indications of Cefmenoxime

For the treatment of infections due to susceptible strains of microorganisms.

Used to treat female gynecologic and obstetric infections caused by susceptible aerobic (including the gonococcus) and anaerobic bacteria.
Intra-Abdominal
For the treatment of serious infections caused by susceptible strains microorganisms.
Lower respiratory tract infections, including pneumonia and lung abscess,s
Urinary tract infections caused by Escherichia coli, Klebsiella species,
Intra-abdominal infections, including peritonitis and intra-abdominal abscess,
Gynecological infections, including endometritis, pelvic cellulitis, and pelvic inflammatory disease caused
Bacterial Infections
Bloodstream Infections
Bone and Joint Infections
Aspiration Pneumonia Cesarean Section

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Contra-Indications of Cefmenoxime

Hemolytic anemia
Liver problems
Interstitial nephritis
Subacute cutaneous lupus erythematosus
Systemic lupus erythematosus
Allergies cephalosporins & beta-lactams

Side Effects of Cefmenoxime

The most common

mild nausea
loss of appetite
vaginal discharge and itching
swelling of feet or legs
chest pain
constipation
local tenderness or pain at the site of injection
skin color change, mild diarrhea
a cough
diarrhea or loose stools
difficulty with breathing
dizziness
heartburn

More common

Abdominal or stomach pain, discomfort, or tenderness
chills or fever
difficulty with moving
a headache, severe and throbbing
joint or back pain
muscle aching or cramping
muscle pains or stiffness
chest pressure or squeezing pain in chest
excessive sweating
feeling of heaviness, pain, warmth and/or swelling in a leg or in the pelvis
sudden tingling or coldness in an arm or leg
sudden slow or difficult speech
sudden drowsiness or need to sleep
fast breathing
sharp pain when taking a deep breath
fast or slow heartbeat
coughing up blood
rust colored urine
decreased amount of urine

Rare

Anxiety
change in vision
seizures
abnormal or fast heart rate
tremors
weight loss
chest pain or tightness
confusion
cough
Agitation
arm, back, or jaw pain
blurred vision
chest pain or discomfort
convulsions
extra heartbeats
fainting
hallucinations
a headache
irritability
lightheadedness
mood or mental changes
muscle pain or cramps

Drug Interactions

Cefmenoxime may interact with the following drugs, supplements, & may change the efficacy of drugs

aminoglycoside antibiotics (e.g., gentamicin, tobramycin)
probenecid
typhoid vaccine
cholera vaccine,
amoxicillin
BCG vaccine
Aspirin Low Strength (aspirin)
Diphenhydramine
Rosuvastatin
Duloxetine
Albuterol
Topiramate
Carbamazepine
Vitamin D3 (cholecalciferol)
Alprazolam
Cetirizine
Phenprocoumon
Picosulfuric acid
Warfarin

Pregnancy Catagory

FDA Pregnancy Category B

Pregnancy

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It is not known if cefmenoxime is safe for use by pregnant women. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

This medication may pass into breast milk. If you are a breast-feeding mother and are taking cefmenoxime it may affect your baby. Talk to your doctor about whether you should continue breast-feeding. It is not known if cefmenoxime is safe for children under 6 months of age.