Avitriptan Drug; Uses, Dosage, Side Effects, Interactions

Avitriptan drug is an antimigraine drug of the triptan family which was never marketed. It acts as a 5-HT_1B and 5-HT_1D receptor agonist. Avitriptan should be able to abort migraine headaches in patients, but may exhibit sumatriptan-like effects on coronary arteries. Initial clinical studies have demonstrated the therapeutic action of the drug in acute migraine.

Mechanism of Action of Avitriptan

Side Effects

The most common

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• leukopenia/leukemia
• hemolytic anemia
• serum sickness
• agranulocytosis
• pain, swelling, irritation where injected
• stomach upset
• sweating
• skin color change, mild diarrhea
• mild nausea
• loss of appetite
• vaginal discharge and itching
• swelling of feet or legs
• chest pain
• constipation
• cough
• diarrhea or loose stools
• difficulty with breathing
• dizziness
• heartburn

More common

• Abdominal or stomach pain, discomfort, or tenderness
• chills or fever
• difficulty with moving
• headache, severe and throbbing
• joint or back pain
• muscle aching or cramping
• muscle pains or stiffness
• chest pressure or squeezing pain in chest
• excessive sweating
• feeling of heaviness, pain, warmth and/or swelling in a leg or in the pelvis
• sudden tingling or coldness in an arm or leg
• sudden slow or difficult speech
• sudden drowsiness or need to sleep
• fast breathing
• sharp pain when taking a deep breath
• fast or slow heartbeat
• coughing up blood
• rust colored urine
• decreased amount of urine

Rare

……………information not available & the product goes to under development, or trialing. Further information

https://pubchem.ncbi.nlm.nih.gov/compound/Avitriptan

References

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