Eperisone HCl; Indications, Dosage, Side Effect, Interactions, Pregnancy

Eperisone HCl; Indications, Dosage, Side Effect, Interactions, Pregnancy

Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex. It is not approved for use in the United States, but is available in other countries like India, South Korea, and Bangladesh.

Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex.

Mechanisms of Action of Eperisone

Mechanisms of action of eperisone on isolated dog saphenous arteries and veins. Eperisonerelaxed saphenous arteries and veins previously contracted with norepinephrine, serotonin, acetylcholine, K+, or Ba2+; but in contrast, it produced contractions in the blood vessels contracted with prostaglandin (PG) F2 alpha.of eperisone on isolated dog saphenous arteries and veins.  Eperisonerelaxed saphenous arteries and veins previously contracted with norepinephrine, serotonin, acetylcholine, K+, or Ba2+; but in contrast, it produced contractions in the blood vessels contracted with prostaglandin (PG) F2 alpha.

Indications of Eperisone

Contra Indications of Eperisone

Eperisone is contraindicated in patients with known hypersensitivity to the drug.Side effects: ‘very rare’ excessive relaxation, stomachache, nausea, vertigo, anorexia, drowsiness, skin rashes, diarrhoea, vomiting, indigestion, GI disturbances, insomnia, headache, constipation etc.

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Dosage of Eperisone

Strengths : 50 mg, 100 mg

Dosage‎: ‎Adult: PO 50 mg 3 times/day
Dose Single Dose Frequency Route Instructions

Adult Dosage

50 mg 50 (50) 8 hourly PO

Paedriatic Dosage (20kg)

Not recommended in this age group

Neonatal Dosage (3kg)

Not recommended in this age group

Side Effects of Eperisone

The most common

Rare

Weakness, dizziness, insomnia, drowsiness, numbness or trembling in the extremities, hepatic and renal dysfunction, haematological changes, skin rashes, itching, GI disturbances, urinary disorders, Rarely, shock.

Drug Interactions of Eperisone

Whenever you take more than one medicine, or mix it with certain foods or beverages, you’re at risk of a drug interaction.

Interaction with Alcohol

Consumption of alcohol can cause severe and potentially irreversible side effects on the liver when taken along with this medicine.

Instructions

You should avoid consuming alcohol while taking myonal 50 MG Tablet. Symptoms like fever, chills, rashes, joint pain and swelling, excessive weakness, nausea should be immediately reported to the doctor.

Interaction with Medicine

Other adverse reactions

5%>   ≥0.1% <0.1% Incidence unknown
Hepatic Elevation of AST

(GOT), ALT(GPT)

and Al-P, etc.

Renal Proteinuria and

Elevation of BUN etc.

 

Hematologic Anemia
Hypersensitivity Rash Pruritus erythema exudativum

multiforme

Psychoneurologic Sleepiness, insomnia,

headache and numbness

in the extremities

 

Stiffness and tremor

in the extremities

Gastrointestinal Nausea/vomiting,

anorexia, stomach discomfort,

abdominal pain, diarrhea,

constipation and thirst

Stomatitis and tremor

in the extremities

Urinary Urinary retention,

urinary incontinence and

the feeling of residual urine

Pregnancy & Lactation

  • Use During Pregnancy eperisone HCl should only be used in pregnant women or women suspected of being pregnant if the expected therapeutic benefits are evaluated to outweigh the possible risk of treatment. The safety of eperisone HCl in pregnant women has not been established.
  • Use During Lactation It is advisable to avoid the administration of eperisone HCl to nursing mothers. When eperisone HCl must be used, breast feeding should be discontinued during treatment.

 

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