Picoprazole; Mechanism, Uses, Contraindications, Dosage, Side effects

Picoprazole; Mechanism, Uses, Contraindications, Dosage, Side effects

Picoprazole is a specific inhibitor of H+/K+-ATPase and binds to 100-kDa polypeptides of the enzyme, dose dependently inhibited opening of the Cl conductance by Cu2+-o-phenanthroline, indicating that or

Picoprazole, inhibited the gastric (H+ + K+)-ATPase in a concentration-and time-dependent manner. Half-maximal inhibition of the (H+ + K+)-ATPase activity was obtained at about 2 . 10(-6)M under standard conditions. In addition to the inhibition of ATPase activity, parallel

Pharmacology of Picoprazole

Picoprazole is a specific inhibitor of H+/K+-ATPase and binds to 100-kDa polypeptides of the enzyme, dose dependently inhibited opening of the Cl conductance by Cu2+-o-phenanthroline, indicating that or

Picoprazole, inhibited the gastric (H+ + K+)-ATPase in a concentration-and time-dependent manner. Half-maximal inhibition of the (H+ + K+)-ATPase activity was obtained at about 2 . 10(-6)M under standard conditions. In addition to the inhibition of ATPase activity, parallel

Mechanism of action of Picoprazole

Picoprazole, like other drugs of the proton pump inhibitor class, works by inhibiting the hydrogen potassium adenosine triphosphatase(H+/K+ ATPase) acid pump. The term “proton pump inhibitor” comes from the recognition of hydrogen as a single proton. H+/K+ ATPase pumps, found in parietal cells in the stomach, are ultimately responsible for secreting acid into the lumen of the stomach. By inhibiting the secretion of acid, proton pump inhibitors are considered to be useful in the treatment of “acid-related diseases” (e.g. gastroesophageal reflux disease).

Medical uses of Picoprazole

Picoprazole is an acid suppressing drug being studied for the treatment of gastroesophageal reflux disease (GERD).

……………………information not available & the product goes to under development, or trialing. Further information

Referances

  1. Literature references related to scientific contents from Springer Nature journals and books. Read more …
  2. PubChem
    Data deposited in or computed by PubChem

    https://pubchem.ncbi.nlm.nih.gov

  3. Target-based classification of drugs

    http://www.genome.jp/kegg-bin/get_htext?br08310.keg

  4. International Patent Classification

    http://www.wipo.int/classifications/ipc/

Picoprazole

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