Category: Cancer, Neoplasms and Palliative Care A – Z

Plasma Cell Myeloma is a neoplastic plasma cell disorder that usually presents after the fifth decade of life; it is rarely described in the younger population especially under 30 years of age. In approximately 2% of plasma cell myeloma, the Read More …

Plasmablastic Lymphoma (PBL) is an uncommon but aggressive subtype of diffuse, large, B-cell lymphoma. The diagnosis of PBL is difficult because its features overlap with myeloma and lymphoma. The primary organs involved are usually the gastrointestinal system, lymph nodes, oral Read More …

Multiple Myeloma (MM) is a fatal, malignant B-cell neoplasm characterized by uncontrolled, destructive growth of mutated plasma cells within the bone marrow (BM). Patients over age 65 are most commonly affected by this disease[rx] and, as indicated by its name, Read More …

MGUS (Monoclonal Gammopathy of Undetermined Significance) is characterized by a serum M protein concentration of less than 30 g/L, fewer than 10% clonal plasma cells in the bone marrow, and the absence of end-organ damage that can be attributed to Read More …

Monoclonal Gammopathy of Undetermined Significance (MGUS) is characterized by a serum M protein concentration of less than 30 g/L, fewer than 10% clonal plasma cells in the bone marrow, and the absence of end-organ damage that can be attributed to Read More …

Lymphoplasmacytic Lymphoma (LPL) is a rare type of non-Hodgkin lymphoma that is characterized by infiltration of small B lymphocytes, plasmacytoid lymphocytes, and plasma cells. The condition most commonly affects the bone marrow, followed by lymph nodes and spleen, and, to Read More …

Follicular Lymphoma (FL) is the second most common type of non-Hodgkin lymphoma (NHL) and accounts for almost 30% of all lymphomas. It is number one among clinically indolent non-Hodgkin lymphomas. FL is a slow-growing B cell lymphoproliferative disorder, and survival Read More …

Hairy Cell Leukemia (HCL) is a relatively rare chronic B-cell malignancy that involves the bone marrow, spleen, and peripheral blood. The complete blood count may reveal pancytopenia including monocytopenia. The median age at diagnosis is approximately 55. Poor prognostic features, Read More …

Splenic Marginal Zone Lymphoma (also known as splenic marginal zone B-cell lymphoma) is one of a family of indolent B-cell lymphomas that remain incompletely characterized. These lymphomas can be globally classified into mucosa-associated lymphatic tissue (MALT) lymphoma, also known as Read More …

B-cell Prolymphocytic Leukemia (B-PLL) is a rare, aggressive leukemia distinct from chronic lymphocytic leukemia. B-PLL is resistant to most chemotherapy and newer targeted therapies such as alemtuzumab and thalidomide. Phenylethyl isothiocyanate (PEITC) is a natural compound from horseradish with evidence Read More …

Lymphoproliferative Disorders (LPD) comprise a heterogeneous group of diseases characterized by uncontrolled production of lymphocytes that cause monoclonal lymphocytosis, lymphadenopathy and bone marrow infiltration. These diseases often occur in immunocompromised individuals. There are two subsets of lymphocytes: T and B Read More …

Monoclonal B Lymphocytosis (MBL) is defined as the presence of a clonal B-cell population in the peripheral blood with fewer than 5 × 109/L B-cells and no other signs of a lymphoproliferative disorder. The majority of cases of MBL have Read More …