Tenoxicam Contraindications, Pregnancy Category

Tenoxicam Contraindications, Pregnancy Category

Tenoxicam Contraindications is an anti-inflammatory agent with analgesic and antipyretic properties is used to treat osteoarthritis and control acute pain. Tenoxicam is a nonsteroidal anti-inflammatory drug (NSAID). It is available as a prescription-only drug in the United Kingdom and other countries, but not in the US. Outside the United Kingdom, tenoxicam is also marketed under brand names including Tilatil, Tilcitin, and Alganex.

Tenoxicam belongs to the class of NSAIDs known as oxicams. It is used to relieve inflammation, swelling, stiffness, and pain associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis (a type of arthritis involving the spine), tendinitis (inflammation of a tendon), bursitis(inflammation of a bursa, a fluid-filled sac located around joints and near the bones), and periarthritis of the shoulders or hips (inflammation of tissues surrounding these joints)

Mechanism of Action of Tenoxicam

The anti-inflammatory effects of tenoxicam may result from the inhibition of the enzyme cyclooxygenase and the subsequent peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, their inhibition accounts for the peripheral analgesic effects of tenoxicam. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss. Tenoxicam is an NSAID which has marked anti-inflammatory and analgesic activity and some antipyretic activity. As with other NSAIDs, the precise mode of action is unknown, though it is probably multifactorial, involving inhibition of prostaglandin biosynthesis and reduction of leucocyte accumulation at the inflammatory site.

or

The anti-inflammatory effects of tenoxicam may result from the inhibition of the enzyme cyclooxygenase and the subsequent peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, their inhibition accounts for the peripheral analgesic effects of tenoxicam. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.

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Tenoxicam Indications

Tenoxicam tablet is used for the treatment, control, prevention, & improvement of the f

Tenoxicam Contraindications

Hypersensitivity to tenoxicam tablet is a contraindication. In addition, Tenoxicam Tablet should not be used if you have the following conditions:

Dosage of Tenoxicam

Strengths: 20 mg

Osteoarthritis, Rheumatoid arthritis 

  • 20 mg as a single dose, taken at the same time each day. Treatment duration: Up to 7 days for acute musculoskeletal disorders and up to 14 days for severe cases.
  • Use the lowest effective dose for the shortest possible duration.
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Acute musculoskeletal disorders, Osteoarthritis, Rheumatoid arthritis

Parenteral

  • Initially, 20 mg IM/IV as a single dose given for 1-2 days, to be continued w/ the oral form, administered at the same time each day.
  • Treatment duration: Up to 7 days for acute musculoskeletal disorders and up to 14 days for severe cases.
  • Use the lowest effective dose for the shortest duration.

Drug Interactions of Tenoxicam

Tenoxicam may interact with following drugs, supplements & may change the efficacy of drugs

Pregnancy Category of Tenoxicam

FDA Pregnancy Category B.

Pregnancy

This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

This medication passes into breast milk. If you are a breastfeeding mother and are taking tenoxicam, it may affect your baby. Talk to your doctor about whether you should continue breastfeeding. The safety and effectiveness of using this medication have not been established for children and adolescents less than 16 years of age.

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References

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