Revaprazan Hydrochloride is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity.It is a drug that reduces gastric acid secretion which is used for the treatment of gastritis. It acts as an acid pump antagonist (potassium-competitive acid blocker). Revaprazan is Read More …
Month: April 2018
Linaprazan; Uses, Dosage, Side Effects, Drug Interactions
Linaprazan is a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity. Linaprazan concentrates highly in the gastric parietal cell canaliculus and on entering this acidic environment is instantly protonated and binds competitively and reversibly to the potassium binding site of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ Read More …
Picoprazole; Mechanism, Uses, Contraindications, Dosage, Side effects
Picoprazole is a specific inhibitor of H+/K+-ATPase and binds to 100-kDa polypeptides of the enzyme, dose dependently inhibited opening of the Cl– conductance by Cu2+-o-phenanthroline, indicating that or Picoprazole, inhibited the gastric (H+ + K+)-ATPase in a concentration-and time-dependent manner. Half-maximal inhibition Read More …
Timoprazole; Mechanism, Uses, Contraindications, Dosage, Side effects,
Timoprazole is in a class of medications called proton pump inhibitors (PPI) that inhibit gastric acid secretion. While it has never come to market, it was studied early on and is considered to be the “backbone” of the PPI class that succeeded it.This medication has Read More …
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Tenatoprazole; Mechanism, Uses, Contraindications, Dosage, Side effects
Tenatoprazole is a proton pump inhibitor drug candidate that was undergoing clinical testing as a potential treatment for reflux oesophagitis and peptic ulcer as far back as 2003. The compound was invented by Mitsubishi Tanabe Pharma and was licensed to Negma Laboratories Mitsubishi reported that tenatoprazole was still in Read More …
Azeloprazole; Uses, Dosage, Side effects, Interactions
Azeloprazole is a drug under investigation for acid-related medical conditions responsive to suppressing the production of stomach acid. It is considered to be a member of the proton pump inhibitor class of medications. Mechanism of action of Azeloprazole Azeloprazole, like other drugs Read More …
Lavoltidine; Uses, Dosage, Side Effects, Interactions
Lavoltidine is a highly potent and selective H2receptor antagonist which was under development & used as a treatment for gastroesophageal reflux disease but was discontinued due to the discovery that it produced gastric carcinoid tumors in rodents. Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking Read More …
Roxatidine; Uses, Dosage, Side Effects, Interactions
Roxatidine is a specific and competitive histamine H2 receptor antagonist drug that is used to treat gastric ulcers, Zollinger–Ellison syndrome, erosive esophagitis, gastro-oesophageal reflux disease, and gastritis. Pharmacodynamic studies showed that 150 mg of roxatidine acetate were optimal in suppressing gastric acid secretion and that a single bedtime dose of 150 mg was more Read More …
Nizatidine; Uses, Dosage, Side Effects, Interactions
Nizatidine is a competitive and reversible histamine H2-receptor antagonist with antacid activity. Nizatidine inhibits the histamine H2-receptors located on the basolateral membrane of the gastric parietal cell, thereby reducing basal and nocturnal gastric acid secretion, resulting in a reduction in gastric volume, acidity, and amount of gastric Read More …
Famotidine; Uses, Dosage, Side effects, Drug Interactions
Famotidine is a propanimidamide and histamine H2-receptor antagonist with antacid activity. As a competitive inhibitor of histamine H2-receptors located on the basolateral membrane of the parietal cell, famotidine reduces basal and nocturnal gastric acid secretion, resulting in a reduction in gastric volume, acidity, and amount of gastric acid released Read More …
Cimetidine; Uses, Dosage, Side Effects, Drug Interactions
Cimetidine is a histamine H(2)-receptor antagonist. Enhancing anti-tumor cell-mediated responses, cimetidine blocks histamine’s ability to stimulate suppressor T lymphocyte activity and to inhibit natural killer (NK) cell activity and interleukin-2 production. Cimetidine also may inhibit tumor growth by suppressing histamine’s growth-factor activity and blocking histamine-induced stimulation of vascular endothelial growth Read More …