Quetiapine is a dibenzothiazepine derivative with the antipsychotic property. Quetiapine fumarate antagonizes serotonin activity mediated by 5-HT 1A and 5-HT2 receptors. With a lower affinity, this agent also reversibly binds to dopamine D1 and D2 receptors in the mesolimbic and mesocortical areas of the brain leading to decreased psychotic Read More …
Month: February 2018
Prazosin; Uses, Dosage, Side Effects, Interactions, Pregnancy
Prazosin is a synthetic piperazine derivative and an alpha-1 adrenergic receptor inhibitor used primarily as an anti-hypertensive. Prazosin’s effects are most pronounced in the large resistance vessels (i.e. arterioles) and result in a decrease in total systemic vascular resistance (SVR) without a rebound or Read More …
Abiraterone; Uses, Dosage, Side Effects, Interactions
Abiraterone is an antiandrogen used to treat metastatic, castration-resistant prostate cancer. Abiraterone is associated with a not uncommon rate of serum enzyme elevation during therapy but has not been clearly linked to cases of clinically apparent liver injury with jaundice. Abiraterone is a steroidal Read More …
Leuprorelin; Uses, Dosage, Side Effects, Interactions, Pregnan
Leuprolide is a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a Read More …
Cetuximab; Uses, Dosage, Side Effects, Interactions, Pregnanc
Cetuximab is an epidermal growth factor receptor (EGFR) inhibitor used for the treatment of metastatic colorectal cancer, metastatic non-small cell lung cancer, and head and neck cancer. It is used to treat a certain type of cancer of the colon (large intestine) or rectum that has spread Read More …
Bortezomib; Uses, Dosage, Side Effects, Interactions, Pregnan
Bortezomib is a dipeptide boronic acid analog with antineoplastic activity. Bortezomib reversibly inhibits the 26S proteasome, a large protease complex that degrades ubiquitinated proteins. By blocking the targeted proteolysis normally performed by the proteasome, bortezomib disrupts various cell signaling pathways, leading to cell cycle arrest, Read More …
Pemetrexed; Uses, Dosage, Side Effects, Interaction, Pregnanc
Pemetrexed is a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyzes the methylation of 2′-deoxyuridine-5′-monophosphate (dUMP) to 2′-deoxythymidine-5′-monophosphate (dTMP), an essential precursor in DNA synthesis. Pemetrexed is a Folate Analog Metabolic Inhibitor. The mechanism of action of pemetrexed is as a Folic Acid Metabolism Inhibitor. or Pemetrexed is a chemotherapy Read More …
Fimasartan; Uses, Dosage, Side Effects, Interactions, Pregnan
Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Concurrent administration of fimasartan with diuretic hydrochlorothiazide has shown to be safe in clinical trials. Fimasartan was approved for use in South Korea on September 9th, 2010 and is available under Read More …
Spironolactone; Uses, Dosage, Side Effects, Drug Interactions
Spironolactone is a potassium-sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on Read More …
Hydrochlorothiazide; Uses, Dosage, Side Effects, Interactions
Hydrochlorothiazide is a thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is Read More …
Furosemide; Uses, Dosage, Side Effects, Interactions, Pregnan
Furosemide is a sulfamoyl anthranilic acid derivative, also known as frusemide, and a potent loop diuretic. Furosemide is widely used to treat hypertension and edema. This agent is highly bound to albumin and is largely excreted unchanged in the urine. Furosemide belongs to the class of medications Read More …
Diuretic; Uses, Types, Side Effects, Drug Interactions
Diuretic is any substance that promotes diuresis, that is, the increased production of urine. This includes forced diuresis. There are several categories of diuretics. All diuretics increase the excretion of water from bodies, although each class does so in a distinct way. Alternatively, an antidiuretic such as vasopressin (antidiuretic hormone), Read More …