Picoprazole; Mechanism, Uses, Contraindications, Dosage, Side effects

Picoprazole is a specific inhibitor of H⁺/K⁺-ATPase and binds to 100-kDa polypeptides of the enzyme, dose dependently inhibited opening of the Cl^– conductance by Cu²⁺-o-phenanthroline, indicating that or

Picoprazole, inhibited the gastric (H+ + K+)-ATPase in a concentration-and time-dependent manner. Half-maximal inhibition of the (H+ + K+)-ATPase activity was obtained at about 2 . 10(-6)M under standard conditions. In addition to the inhibition of ATPase activity, parallel

Pharmacology of Picoprazole

Picoprazole is a specific inhibitor of H⁺/K⁺-ATPase and binds to 100-kDa polypeptides of the enzyme, dose dependently inhibited opening of the Cl^– conductance by Cu²⁺-o-phenanthroline, indicating that or

Picoprazole, inhibited the gastric (H+ + K+)-ATPase in a concentration-and time-dependent manner. Half-maximal inhibition of the (H+ + K+)-ATPase activity was obtained at about 2 . 10(-6)M under standard conditions. In addition to the inhibition of ATPase activity, parallel

Mechanism of action of Picoprazole

Picoprazole, like other drugs of the proton pump inhibitor class, works by inhibiting the hydrogen potassium adenosine triphosphatase(H⁺/K⁺ ATPase) acid pump. The term “proton pump inhibitor” comes from the recognition of hydrogen as a single proton. H⁺/K⁺ ATPase pumps, found in parietal cells in the stomach, are ultimately responsible for secreting acid into the lumen of the stomach. By inhibiting the secretion of acid, proton pump inhibitors are considered to be useful in the treatment of “acid-related diseases” (e.g. gastroesophageal reflux disease).

Medical uses of Picoprazole

Picoprazole is an acid suppressing drug being studied for the treatment of gastroesophageal reflux disease (GERD).

……………………information not available & the product goes to under development, or trialing. Further information

Referances

1. ChemIDplus
   Picoprazole [INN]

   https://chem.nlm.nih.gov/chemidplus/sid/0078090116

   ChemIDplus Chemical Information Classification

   https://chem.sis.nlm.nih.gov/chemidplus/chemidheavy.jsp

2. Springer Nature
   Literature references related to scientific contents from Springer Nature journals and books. Read more …
3. Wikipedia
   picoprazole

   https://www.wikidata.org/wiki/Q27289045

4. PubChem
   Data deposited in or computed by PubChem

   https://pubchem.ncbi.nlm.nih.gov

5. MeSH
   picoprazole

   https://www.ncbi.nlm.nih.gov/mesh/67028887

   MeSH Tree

   http://www.nlm.nih.gov/mesh/meshhome.html

6. KEGG
   Target-based classification of drugs

   http://www.genome.jp/kegg-bin/get_htext?br08310.keg

7. WIPO
   International Patent Classification

   http://www.wipo.int/classifications/ipc/

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