Cefuzonam; Uses, Contraindications, Dosage, Side effects, Interaction

Cefuzonam is an injectable, semi-synthetic second-generation cephalosporin with broad-spectrum antibiotic activity.it is a second-generation cephalosporin type of antibiotic medication used to treat bacterial infections. Its antibacterial activity is due to the presence of a beta-lactam core structure, which binds with penicillin-binding proteins within bacterial cells, thereby inhibiting cell wall synthesis.

Mechanism of Action of Cefuzonam

Cephalosporins exert bactericidal activity by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan. The cephalosporins are also thought to play a role in the activation of bacterical cell autolysins which may contribute to bacterial cell lysis.

Indications of Cefuzonam

• Acute Bacterial Exacerbation of Chronic Bronchitis 
• Bladder Infection
• Kidney Infections
• Bronchitis
• Otitis Media
• Pneumonia
• Sinusitis
• Skin or soft tissue infection
• Tonsillitis/Pharyngitis
• Upper respiratory tract infection
• Bacterial infections
• Community acquired pneumonia
• Streptococcal pharyngitis
• Streptococcal tonsillitis
• Urinary tract Infections 
• Uncomplicated skin and subcutaneous tissue bacterial infections

Contra Indications of Cefuzonam

• Clostridium difficile infection
• Decrease in the Blood-Clotting Protein Prothrombin
• severe renal impairment
• Liver problems
• Interstitial Nephritis
• Subacute cutaneous lupus erythematosus
• Systemic Lupus Erythematosus
• Allergies cephalosporins & betalactams

Side Effects of Cefuzonam

The most common

• Nausea and vomiting
• Abdominal or stomach pain, discomfort, or tenderness
• Severe stomach ache
• Severe diarrhea
• Vaginal thrush
• Skin rash
• Headache
• chest pain
• constipation
• cough
• diarrhea or loose stools
• difficulty with breathing
• dizziness
• heartburn
• muscle pain

More common

• Abdominal or stomach pain, discomfort, or tenderness
• chills or fever
• difficulty with moving
• headache, severe and throbbing
• joint or back pain
• muscle aching or cramping
• muscle pains or stiffness
• chest pressure or squeezing pain in chest
• discomfort in arms, shoulders, neck or upper back
• excessive sweating
• feeling of heaviness, pain, warmth and/or swelling in a leg or in the pelvis
• sudden tingling or coldness in an arm or leg
• sudden slow or difficult speech
• sudden drowsiness or need to sleep
• fast breathing
• sharp pain when taking a deep breath
• fast or slow heartbeat
• coughing up blood
• rust colored urine
• decreased amount of urine

Rare

• Anxiety
• change in vision
• seizures
• abnormal or fast heart rate
• tremors
• weight loss
• chest pain or tightness
• confusion
• cough
• Agitation
• arm, back, or jaw pain
• blurred vision
• chest pain or discomfort
• convulsions
• extra heartbeats
• fainting
• hallucinations
• headache
• irritability
• lightheadedness
• mood or mental changes
• muscle pain or cramps
• muscle spasm or jerking of all extremities

Data or information not availabe. For furthers inquery …..

https://pubchem.ncbi.nlm.nih.gov/compound/Cefuzonam

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