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Cefamandole; Uses, Dosage, Side Effects, Interactions

Cefamandole is a second-generation cephalosporin antibiotic with bactericidal activity. Cefamandole is active against Haemophilus and gram-negative bacilli susceptible to other cephalosporins. It is also active against many strains resistant to other cephalosporins, such as Enterobacter species and indole-positive Proteus species.

Cefamandole is only found in individuals that have used or taken this drug. It is a broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally. Cefamandole is no longer available in the United States. Like all beta-lactam antibiotics, cefamandole binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefamandole interferes with an autolysin inhibitor.

Mechanism of Action of Cefamandole

Like all beta-lactam antibiotics, cefamandole binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefamandole interferes with an autolysin inhibitor.The bactericidal action of cefamandole results from inhibition of cell-wall synthesis. Cephalosporins have in vitro activity against a wide range of gram-positive and gram-negative organisms.

Indications of Cefamandole

Pneumonia
Skin or soft tissue infection
Surgical prophylaxis
Urinary tract infection
Aspiration pneumonia cesarean section
Bronchitis
Tonsillitis
Endometritis
Flu caused by Influenza
Infected animal bite
Intra-Abdominal Infections
Lower respiratory tract infection bacterial
Peritonitis
Skin and Subcutaneous Tissue Bacterial Infections
Skin and skin structure infections caused by Staphylococcus aureus

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Contra-Indications of Cefamandole

Clostridium difficile infection
The decrease in the blood-clotting protein prothrombin
Severe renal impairment
Inadequate vitamin K
Hemolytic anemia
Liver problems
Interstitial nephritis
Subacute cutaneous lupus erythematosus
Systemic lupus erythematosus
Allergies cephalosporins & beta-lactams

Dosage of Cefamandole

Strengths: 500 mg to 1 g

Pneumonia

The usual dosage range for cefamandole (cefamandole) e is 500 mg to 1 g every 4 to 8 hours.

Infections of skin structures

500 mg every 6 hours is adequate.

Uncomplicated pneumonia,

500 mg every 6 hours is adequate.

Uncomplicated urinary tract infections,

500 mg every 8 hours is sufficient. In more
serious urinary tract infections, a dosage of 1 g every 8 hours may be needed.
In severe infections, 1-g doses may be given at 4 to 6-hour intervals.

In life-threatening infections or infections due to less susceptible organisms,

doses up to 2 g every 4 hours (ie, 12 g/day) may be needed.

Infants and Children

Administration of 50 to 100 mg/kg/ day in equally divided doses every 4 to 8 hours has been effective for most infections susceptible to (cefamandole).
This may be increased to a total daily dose of 150 mg/kg (not to exceed the maximum adult dose) for severe infections.

Side Effects

The most common

More common

Abdominal or stomach pain, discomfort, or tenderness
chills or fever
difficulty with moving
a headache, severe and throbbing
joint or back pain
muscle aching or cramping
muscle pains or stiffness
chest pressure or squeezing pain in the chest
excessive sweating
feeling of heaviness, pain, warmth and/or swelling in a leg or in the pelvis
sudden tingling or coldness in an arm or leg
sudden slow or difficult speech
sudden drowsiness or need to sleep
fast breathing
sharp pain when taking a deep breath
fast or slow heartbeat
coughing up blood
rust colored urine
decreased amount of urine

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Rare

Anxiety
change in vision
seizures
abnormal or fast heart rate
tremors
weight loss
chest pain or tightness
confusion
a cough
Agitation
arm, back, or jaw pain
blurred vision
chest pain or discomfort
convulsions
extra heartbeats
fainting
hallucinations
a headache
irritability
lightheadedness
mood or mental changes
muscle pain or cramps

Drug Interactions of Cefamandole

Cefamandole may interact with the following drugs, supplements, & may change the efficacy of drugs

aminoglycoside antibiotics (e.g., gentamicin, tobramycin)
probenecid
typhoid vaccine
cholera vaccine,
amoxicillin
Aspirin Low Strength (aspirin)
Diphenhydramine
Rosuvastatin
Duloxetine
Albuterol
Topiramate
Carbamazepine
Vitamin B12 (cyanocobalamin)
Vitamin D3 (cholecalciferol)
Alprazolam
Cetirizine
Phenprocoumon
Picosulfuric acid
Warfarin

Pregnancy Catagory of Cefamandole

FDA Pregnancy Category B

Pregnancy

There are no well-done studies that have been done in humans with Cefamandole. But in animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.

Lactation

In animal studies, pregnant animals were given Cefamandole, and some babies had problems. But in human studies, pregnant women were given this medication and their babies did not have any problems related to this medication.