Sepia ink polysaccharide (SIP) isolated from squid and cuttlefish ink is a kind of acid mucopolysaccharide that has been identified in three types of primary structures from squid (Illex argentinus and Ommastrephes bartrami), cuttlefish Sepiella maindroni, and cuttlefish Sepia esculenta ink. Although SIP has been proved to be multifaceted, most of the reported evidence has illuminated its chemopreventive and antineoplastic activities. As a natural product playing a role in cancer treatment, SIP may be used as a chemotherapeutic ancillary agent or functional food. Based on the current findings on SIP, we have summarized four topics in this review, including: chemopreventive, antineoplastic, chemosensitive, and procoagulant and anticoagulant activities, which are correlative closely with the actions of anticancer agents on cancer patients, such as anticancer, toxicity and thrombogenesis, with the latter two actions being common causes of death in cancer cases exposed to chemotherapeutic agents.
Materia Medica of Sepia
- Mind – Irritable; holds everything in contempt. Full of desires, for what they know not.
- Head – Bones of skull feel crushed or bruised. Pain extends to teeth and root of the tongue.
- Eyes – Inflamed, red. Pain through eyeballs. Profuse lachrymation. Cornea dim. Eyes tire from near vision. State of vision constantly changing. Spasm of accommodation from the irritable weakness of the ciliary muscle. Nausea from looking on moving objects.
- Face – Blue rings around eyes. Periodical orbital neuralgia, with lachrymation, photophobia, and smarting eyelids.
- Nose – Coryza, with stoppage of nose and nausea. Epistaxis.
- Stomach – Tongue usually clean. Mouth, moist; much saliva. Constant nausea and vomiting, with pale, twitching of face. Vomits food, bile, blood, mucus. Stomach feels relaxed as if hanging down. Hiccough.
- Abdomen – Amebic dysentery with tenesmus; while straining pain so great that it nauseates; little thirst. Cutting, clutching; worse, around the navel. Body rigid; stretched out stiff.
- Stools – Pitch-like green as grass, like frothy molasses, with griping at the navel. Dysenteric, slimy.
- Female – Uterine hæmorrhage, profuse, bright, gushing, with nausea. Vomiting during pregnancy. Pain from navel to the uterus. Menses too early and too profuse.
- Respiratory – Dyspnœa; constant constriction in chest. Asthma. Yearly attacks of difficult shortness of breathing. Continued sneezing; coryza; a wheezing cough. A cough incessant and violent, with every breath. Chest seems full of phlegm but does not yield to coughing. Bubbling rales. A suffocative cough; the child becomes stiff, and blue in the face. Whooping-cough, with a nosebleed, and from the mouth. Bleeding from lungs, with nausea; feeling of constriction; rattling cough. Croup. Hæmoptysis from slightest exertion (Millef). Hoarseness, especially at end of a cold. Complete aphonia.
- Fever – Intermittent fever, irregular cases, after Quinine. Slightest chill with much heat, nausea, vomiting, and dyspnœa. Relapses from improper diet.
- Sleep – With eyes half open. Shocks in all limbs on going to sleep (Ign).
- Extremities – Body stretched stiff, followed by spasmodic jerking of arms towards each other.
- Skin – Pale, lax. Blue around eyes. Military rash.
Indications of Sepia
- Pre-Menstrual Syndrome (PMS) – The Sepia woman may appear indifferent and/or irritable prior to her period, often taking her foul mood out on those closest to her (i.e., her partner or children). She will be fatigued, snappy, and chilly, and markedly worse for missing meals.
- Candida Albicans, also known as yeast infections – A person requiring Sepia will likely experience extreme vaginal itchiness, accompanied by a yellow or greenish discharge.
- Headaches and migraines – Sepia women tend towards migraines (worse before or during her period, during pregnancy, or before a thunderstorm) which start over the left eye and may extend to the nape of the neck.
- Complaints of Pregnancy – Pregnant women are often catapulted into a Sepia state on becoming pregnant, suffering from chloasma (the “mask of pregnancy”), morning sickness (worse from the sight/smell of food), extreme weariness, and constipation. Those lacking emotional or physical support, experiencing headache, varicose veins, and constipation would likely benefit from Sepia, as are women who have a history of miscarriage around five and seven months of pregnancy. Expectant mothers who already have children are especially prone to a Sepia state.
- Post-Partum Complaints – Women who have a lack of interest in their families, irritability and lowered energy (sexual and otherwise), are all Sepia candidates.
- Menopause – Think of Sepia in all cases of hormonal imbalance. The menopause of Sepia is typified by hair loss, irritability, hot flashes, profuse night sweats, and leaving the woman feeling overwhelmed and/or indifferent. Sepia women may have involuntary attacks of weeping, without knowing why.
- Circulatory Problems – Sepia women, with their innate desire to keep moving, are especially prone to stasis and stagnation. Apart from overall chilliness, and especially coldness of the extremities, they may likely suffer from varicose veins and bleeding, protruding hemorrhoids (often accompanied by constipation).
- Bloating and lower back pain during menstruation
- Amenorrhoea
- Appetite, depraved
- Baldness
- Bladder, irritable
- Cystitis
- Dandruff
- Dysmenorrhoea
- Dyspepsia
- Gonorrhea
- Jaundice
- Leucorrhoea
- Menstruation, disorder
- Neuralgia
- Pregnancy, disorders of, vomiting of Pruritus. Psoriasis
- Ptosis
- Seborrhoea
- Spermatorrhoea
- A toothache
- Urine, incontinence
- Varicose veins
- Warts
- Whooping-cough
Dosage of Sepia
- Adult and children 2 years of age and older: Dissolve 5 pellets under the tongue 3 times a day until relieved or as directed by a doctor.
- Homeopathic treatment sepia 200 4pills one dose only followed by pl 4pills 2times for 1 week and revert back.
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