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Mebeverine; Uses, Dosage, Side Effects, Interactions, Pregnancy

Mebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms. Mebeverine is a drug used to alleviate some of the symptoms of irritable bowel syndrome. It works by relaxing the muscles in and around the gut. It is a direct relaxant of gut (intestinal) muscle and is sometimes known as an antispasmodic drug. It is used to relax the muscles of the intestine and to treat symptoms of irritable bowel syndrome and related conditions.

Mechanism of Action of Mebeverine

Mebeverine is an anticholinergic but its mechanism of action is not known; it appears to work directly on smooth muscle within the gastrointestinal tract and may have an anesthetic effect, may affect calcium channels, and may affect muscarinic receptors. It is metabolized mostly by esterases, and almost completely. The metabolites are excreted in urine.

Indications of Mebeverine

Irritable bowel syndrome
Chronic irritable colon
Spastic constipation
Mucous colitis
Spastic colitis
It is a direct relaxant of gut (intestinal) muscle and is sometimes known as an antispasmodic drug.
It is used to relax the muscles of the intestine and to treat symptoms of irritable bowel syndrome and related conditions.
In general, this drug is used to manage the symptoms of irritable bowel syndrome, a common intestinal condition which causes spasm and pain in the intestine, as well as stomach pain, persistent diarrhea (sometimes alternating with periods of constipation) and wind (flatulence).
Benefits of being on this drug include reducing the painful and troublesome symptoms of irritable bowel syndrome.

Contra-Indications of Mebeverine

Hypersensitivity

Dosage of Mebeverine

Strengths: 135 mg

PO GI tract spasm

Irritable bowel syndrome 135 mg tTID may reduce gradually after several wk when the desired effect has been obtained; 100 mg tid has also been used.
As modified-release cap: 200 mg bid.

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Gastrointestinal tract spasm, Irritable bowel syndrome

135 mg tid, may reduce gradually after several wk when the desired effect has been obtained;
100 mg tid has also been used. As modified-release cap: 200 mg bid.

Side Effects

The most common

More common

Fast or irregular heartbeat
fever
Back pain
dizziness
ha eadache
increased cough
Acid or sour stomach
decreased appetite
chest congestion
chest pain
cold sweats
confusion
decreased sexual ability or desire
diarrhea or loose stools
heartburn
sleepiness or unusual drowsiness
stomach or abdominal cramps, gas, or pain
trouble sleeping

Drugs Interactions of Mebeverine

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: none known.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of none has known

This information does not contain all possible interactions. Therefore, before using mebeverine, tell your doctor or pharmacist of all the products you use.

Pregnancy & Lactation of Mebeverine

FDA Pregnancy Category – N (Not Assigned)

Pregnancy

Several studies have suggested an increased risk of congenital malformations associated with the use of minor tranquilizers (i.e., chlordiazepoxide, diazepam, meprobamate) during the first trimester of pregnancy. There are no adequate studies in pregnant women.