Mebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms. Mebeverine is a drug used to alleviate some of the symptoms of irritable bowel syndrome. It works by relaxing the muscles in and around the gut. It is a direct relaxant of gut (intestinal) muscle and is sometimes known as an antispasmodic drug. It is used to relax the muscles of the intestine and to treat symptoms of irritable bowel syndrome and related conditions.
Mechanism of Action of Mebeverine
Mebeverine is an anticholinergic but its mechanism of action is not known; it appears to work directly on smooth muscle within the gastrointestinal tract and may have an anesthetic effect, may affect calcium channels, and may affect muscarinic receptors. It is metabolized mostly by esterases, and almost completely. The metabolites are excreted in urine.
Indications of Mebeverine
- Irritable bowel syndrome
- Chronic irritable colon
- Spastic constipation
- Mucous colitis
- Spastic colitis
- It is a direct relaxant of gut (intestinal) muscle and is sometimes known as an antispasmodic drug.
- It is used to relax the muscles of the intestine and to treat symptoms of irritable bowel syndrome and related conditions.
- In general, this drug is used to manage the symptoms of irritable bowel syndrome, a common intestinal condition which causes spasm and pain in the intestine, as well as stomach pain, persistent diarrhea (sometimes alternating with periods of constipation) and wind (flatulence).
- Benefits of being on this drug include reducing the painful and troublesome symptoms of irritable bowel syndrome.
Contra-Indications of Mebeverine
Dosage of Mebeverine
- Strengths: 135 mg
PO GI tract spasm
- Irritable bowel syndrome 135 mg tTID may reduce gradually after several wk when the desired effect has been obtained; 100 mg tid has also been used.
- As modified-release cap: 200 mg bid.
Gastrointestinal tract spasm, Irritable bowel syndrome
- 135 mg tid, may reduce gradually after several wk when the desired effect has been obtained;
- 100 mg tid has also been used. As modified-release cap: 200 mg bid.
The most common
- allergic reactions,
- immune system disorders,
- skin disorders including hives,
- edema and widespread rashes
- dry mouth
- chest pain
- ha eadache
- joint painPain
- nausea and vomiting
- Severe stomach ache,
- ha eadache,
- fainting, fast or pounding heartbeats.
- Fast or irregular heartbeat
- Back pain
- ha eadache
- increased cough
- Acid or sour stomach
- decreased appetite
- chest congestion
- chest pain
- cold sweats
- decreased sexual ability or desire
- diarrhea or loose stools
- sleepiness or unusual drowsiness
- stomach or abdominal cramps, gas, or pain
- trouble sleeping
Drugs Interactions of Mebeverine
This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: none known.
Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of none has known
This information does not contain all possible interactions. Therefore, before using mebeverine, tell your doctor or pharmacist of all the products you use.
FDA Pregnancy Category – N (Not Assigned)
Several studies have suggested an increased risk of congenital malformations associated with the use of minor tranquilizers (i.e., chlordiazepoxide, diazepam, meprobamate) during the first trimester of pregnancy. There are no adequate studies in pregnant women.