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Fimasartan; Uses, Dosage, Side Effects, Interactions, Pregnan

Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Concurrent administration of fimasartan with diuretic hydrochlorothiazide has shown to be safe in clinical trials. Fimasartan was approved for use in South Korea on September 9th, 2010 and is available under the brand name Kanarb through Boryung Pharmaceuticals, who are presently seeking worldwide partnership.

Mechanism of Action of Fimasartan

Angiotensin II activates AR1 leading to vasoconstriction and increased noradrenaline release which further increases vasoconstriction via action at α1-adrenergic receptors.. It also stimulates secretion of aldosterone which acts to increase sodium and water reabsorption in the renal tubules. Fimasartan bind to and antagonizes AR1 preventing vasoconstriction and reducing aldosterone secretion to increase natriuresis leading to a reduction in blood volume. Together these effects produce an anti-hypertensive effect.

Indications of Fimasartan

High Blood Pressure
Lowering high blood pressurehelps prevent strokes, heart attacks, and kidney problems.
It acts to lower blood pressure by inhibiting vasoconstriction
Used for the treatment of hypertension and heart failure
Isolated systolic hypertension,
Left ventricular hypertrophy
Diabetic Nephropathies
High Blood Pressure (Hypertension)
Second line agent in the treatment of congestive heart failure,
Systolic dysfunction,
Myocardial infarction and coronary artery disease in those intolerant of ACE inhibitors
Risk of stroke in patients with hypertension and left ventricular hypertrophy.
Diabetic nephropathy with an elevated serum creatinine and proteinuria

Conta Indications of Fimasartan

Kidney problems
Heart problems
Recent excessive vomiting or diarrhoea
A condition called primary hyperaldosteronism.
High amount of potassium in the blood
Renal artery stenosis
Abnormally low blood pressure
Liver problems
Mild to moderate kidney impairment
Pregnancy
Decreased blood volume

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Side Effects of Fimasartan

Most common

dry mouth,
Increase the feeling of thurst
increase the frequency of urination
Abdominal or stomach discomfort
low blood pressure,
difficult, burning, or painful urination
increased potassium blood levels (hyperkalemia),
low blood sugar (hypoglycemia), and
diarrhea
symptoms of weakness, muscle pain (myalgia)
abdominal pain (GI complaints), lactic acidosis (rare)
low blood levels of vitamin B-12
nausea,vomiting
chest discomfort
chills, dizziness
bloating/abdominal distention
constipation
heartburn

More common

chest pain;
Abdominal or stomach discomfort
cough or hoarseness
decreased appetite
diarrhea
fast or shallow breathing
trouble breathing; or
dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure)
lower back or side pain
muscle pain or cramping
painful or difficult urination