Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Concurrent administration of fimasartan with diuretic hydrochlorothiazide has shown to be safe in clinical trials. Fimasartan was approved for use in South Korea on September 9th, 2010 and is available under the brand name Kanarb through Boryung Pharmaceuticals, who are presently seeking worldwide partnership.
Mechanism of Action of Fimasartan
Angiotensin II activates AR1 leading to vasoconstriction and increased noradrenaline release which further increases vasoconstriction via action at α1-adrenergic receptors.. It also stimulates secretion of aldosterone which acts to increase sodium and water reabsorption in the renal tubules. Fimasartan bind to and antagonizes AR1 preventing vasoconstriction and reducing aldosterone secretion to increase natriuresis leading to a reduction in blood volume. Together these effects produce an anti-hypertensive effect.
Indications of Fimasartan
- High Blood Pressure
- Lowering high blood pressurehelps prevent strokes, heart attacks, and kidney problems.
- It acts to lower blood pressure by inhibiting vasoconstriction
- Used for the treatment of hypertension and heart failure
- Isolated systolic hypertension,
- Left ventricular hypertrophy
- Diabetic Nephropathies
- High Blood Pressure (Hypertension)
- Second line agent in the treatment of congestive heart failure,
- Systolic dysfunction,
- Myocardial infarction and coronary artery disease in those intolerant of ACE inhibitors
- Risk of stroke in patients with hypertension and left ventricular hypertrophy.
- Diabetic nephropathy with an elevated serum creatinine and proteinuria
Conta Indications of Fimasartan
- Kidney problems
- Heart problems
- Recent excessive vomiting or diarrhoea
- A condition called primary hyperaldosteronism.
- High amount of potassium in the blood
- Renal artery stenosis
- Abnormally low blood pressure
- Liver problems
- Mild to moderate kidney impairment
- Pregnancy
- Decreased blood volume
Side Effects of Fimasartan
Most common
- dry mouth,
- Increase the feeling of thurst
- increase the frequency of urination
- Abdominal or stomach discomfort
- low blood pressure,
- difficult, burning, or painful urination
- increased potassium blood levels (hyperkalemia),
- low blood sugar (hypoglycemia), and
- diarrhea
- symptoms of weakness, muscle pain (myalgia)
- abdominal pain (GI complaints), lactic acidosis (rare)
- low blood levels of vitamin B-12
- nausea,vomiting
- chest discomfort
- chills, dizziness
- bloating/abdominal distention
- constipation
- heartburn
More common
- chest pain;
- Abdominal or stomach discomfort
- cough or hoarseness
- decreased appetite
- diarrhea
- fast or shallow breathing
- trouble breathing; or
- dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure)
- lower back or side pain
- muscle pain or cramping
- painful or difficult urination
Less common
- dry mouth
- feeling of thirst
- weakness
- drowsiness
- restlessness
- muscle pains or cramps
- fast or abnormal heartbeat
- severe nausea or vomiting
- tiredness
- weakness
- dry hair and skin
- increased feelings of being cold
- pain when you eat or drink
- severe nausea or vomiting
…………………………Ferther information is not available
References
