Cefmetazole is a second-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefmetazole binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted. Cefmetazole is a semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date, no severe side effects have been noted.
Cefmetazole is only found in individuals that have used or taken this drug. It is a semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date, no severe side effects have been noted. [PubChem]The bactericidal activity of cefmetazole results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins.

Mechanism of action of Cefmetazole

The bactericidal activity of cefmetazole results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefmetazole is a second-generation cephalosporin. The cephalosporins are bactericidal drugs with both gram-positive and gram-negative activity. They inhibit bacterial cell wall synthesis in a way similar to the penicillins. Cefmetazole is more active than 1st-generation cephalosporins against indole-positive Proteus, Serratia, anaerobic gram-negative bacilli (including B. fragilis), and some E. coli, Klebsiella, and P. mirabilis, but is less active than cefoxitin or cefotetan against most gram-negative bacilli.

Indications of Cefmetazole

For the treatment of infections caused by susceptible organisms.

  • For the treatment of serious infections caused by susceptible strains microorganisms.
  • Lower respiratory tract infections, including pneumonia and lung abscess,s
  •  Urinary tract infections caused by Escherichia coli, Klebsiella species,
  • Intra-abdominal infections, including peritonitis and intra-abdominal abscess,
  • Gynecological infections, including endometritis, pelvic cellulitis, and pelvic inflammatory
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Cefmetazole, Contra-Indications

  • Liver problems
  • Interstitial nephritis
  • Subacute cutaneous lupus erythematosus
  • Systemic lupus erythematosus
  • Allergies cephalosporins & beta-lactams

Cefmetazole Side Effects 

The most common

More common

Rare

Cefmetazole Drug Interactions

Cefmetazole may interact with following drugs, suppliments, & may change the efficacy of drugs

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Pregnancy Catagory of Cefmetazole

FDA Pregnancy Category  B

Pregnancy

It is not known if cefmetazole is safe for use by pregnant women. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

This medication may  passes into breast milk. If you are a breast-feeding mother and are taking cefmetazole it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.It is not known if cefmetazole is safe for children under 6 months of age.

References

Cefmetazole

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