Intramyocardial infusion-needle catheter ablation

Transcoronary alcohol ablation has emerged to approach deep intramyocardial substrate in patients not amenable to endo-epicardial catheter ablation (mechanical valve, thrombus, significant comorbidities)[rx,rx]. Transcoronary alcohol ablation requires the injected dose of sterile pure ethanol with proximal balloon expansion to a culprit vessel with a target of abolishing perfusion[rx,rx] . This method can prevent recurrent VT, VT storm and can control incessant VT[rx,rx]. The exact recognition of the target vessel and the existence of collaterals may hinder the adoption of the method[rx–rx].

Transcoronary alcohol ablation. Coronary angiography of the left anterior descending artery shows a septal perforator with a course to the site of the earliest activity. A balloon catheter occludes this branch and ethanol is infused (blue arrows). The ablation catheter is placed in the region of the earliest activity (red circle).

Kim et al[rx] introduced the novel use of cardioplegia as a mapping technique in order to identify the critical VT isthmus to facilitate effective transcoronary ethanol ablation and avoid irreversible myocardial injury. Furthermore, Sapp et al[rx] showed that intramyocardial needle mapping and ablation with saline infusion could create deep injuries and is a practical and efficient method. Intracoronary wire mapping and coil embolization have also been utilized just as alcohol ablation to target VT arising from intraventricular septum[rx]. After intracoronary wire mapping and recognition of a culprit’s vessel, coils are directed to embolize the branch, eliminating the desired target perfusion[rx].

Bipolar ablation

Bipolar ablation between two ablation catheters located on either position of the septum from both ventricles improves lesion transmurality because it depends less on catheter contact and alignment[rx,rx]. Bipolar ablation has the theoretical benefit of producing more powerful energy and providing deeper lesions, in comparison to two separate unipolar catheters[rx,rx]. Sakamoto et al[rx] recently successfully eliminated the critical VT circuit in a patient with an arrhythmogenic substrate (cardiac sarcoidosis), utilizing bipolar ablation.

Cardiac sympathetic denervation

Accumulated evidence strongly suggests the role of sympathetic neuromodulation in controlling refractory VT[rx–rx]. Cardiac sympathetic denervation surgery has been proven to be useful for the management of congenital long QT syndrome and catecholaminergic polymorphic VT[rx]. The procedure requires extraction of the lower fraction of the stellate ganglion and T2-T4 sympathetic thoracic ganglia[rx]. Complications regarding the procedure were infrequent, with 4% developing acute ptosis or Horner syndrome[rx]. Vaseghi et al[rx] showed that cardiac sympathetic denervation has greater shock-free survival as well as a considerable decline in shock burden in patients with recurrent VT or VT storm, regardless of antiarrhythmic drug therapy and catheter ablation. In addition, bilateral cardiac sympathetic denervation appeared to be more efficacious than left-sided denervation[rx,rx].

Augmented sympathetic activity leads to early and delayed afterdepolarization, enhances diffuse repolarization, leading to ventricular electrical susceptibility and increases the possibility of malignant VT[rx]. Stellate ganglionectomy lengthens the ventricular refractory period and raises the VF threshold, decreasing VT or VF inducibility in the context of myocardial infarction[rx,rx]. Locally invasive sympathetic ganglion block could select individuals with greater possibilities of long-term clinical benefits prior to sympathetic denervation[rx,rx].

Renal sympathetic denervation

Enhanced sympathetic tone shortens the ventricular effective refractory period, enhances automaticity, and lowers the threshold for ventricular arrhythmias[rx–rx]. Feyz et al[rx] performed bilateral renal denervation in a patient with polymorphic VT with excellent results. Aksu et al[rx] also showed that catheter-based renal denervation was successful in a patient with an electrical storm due to catecholaminergic polymorphic VT. However, the microanatomy of human renal vessels has great variability. Accessory renal vessels that bifurcated early can also influence the result negatively, and there is still the absence of procedural endpoint during the technique[rx].

As a result, renal sympathetic denervation is not currently recognized as an ideal or approved VT treatment method[rx–rx]. However, certain ventricular arrhythmias do not terminate after catheter ablation, thus making renal sympathetic denervation a possible option for patients in whom other ablative approaches were ineffective[rx,rx].

Stereotactic radioactive therapies

Despite catheter-oriented ablation, which applies radiofrequency or freezing to damaged tissues, radiotherapy is based on photons from X-rays or gamma rays to injure the desired target, mainly cancer. Through novel distribution methods such as intensity-modulated radiotherapy, a dosage of radiotherapy can be precisely and accurately directed to the desired size, while diminishing dosage to adjoining healthy tissues[rx,rx].

Ablative radiotherapy is generally a noninvasive, outpatient method, which does not involve anesthesia[rx,rx]. Potential risks consist of damage to tissue next to the ablated site, such as brain edema for intracranial lesions, pneumonitis for chest therapies, myelopathy for spinal carcinomas, or bowel perforation for abdominal locations[rx,rx]. In comparison to radiofrequency or cryo energy, the damage from ablative radiotherapy progresses over days to months, needing time for the total tissue damage to be shown[rx,rx].

The first patient was treated on a robotic radiosurgery system (CyberKnife^®, Accuray, Sunnyvale, CA, United States) in 2012[rx]. The follow-up revealed no definite acute or late adverse effects, and a seven-month reduction burden in VT on standard antiarrhythmic drug therapy, suggesting a potential transient benefit of this method[rx].

Cuculich et al[rx] investigated five patients with increased-risk, refractory VT. The authors focused on arrhythmogenic scar sites by merging anatomical imaging with noninvasive electrocardiographic imaging during VT that was produced using an ICD[rx]. Patients were treated with a single dose of 25 Gy while awake, using a noninvasive distribution of accurate ablative radiation with stereotactic body radiation treatment[rx]. Cuculich et al[rx] reported a reduction in events of VT in all five patients.

Cryoablation

Catheter radiofrequency ablation of VT originating from the left ventricle’s papillary muscles has been linked to conflicting outcomes[rx,rx]. Rivera et al[rx] investigated twenty-one patients with drug-refractory VT, who underwent catheter cryoablation or radiofrequency ablation. Cryoablation was correlated with greater success rates and smaller recurrence rates than radiofrequency procedures, superior catheter support, and smaller frequency of polymorphic arrhythmias[rx]. Marai et al[rx] recently used cryoablation guided by intracardiac echocardiography, 3-dimensional mapping system, and image integration to treat a patient with refractory VT originating from papillary muscle with excellent results.

Surgical therapy for VT

Catheter ablation provides efficient outcomes for sustained monomorphic VT, but certain situations, such as the existence of mural thrombus and heavy calcification, can lead to adverse results[rx,rx]. Higuchi et al[rx] successfully treated a 67-year-old patient with sustained monomorphic VT due to ventricular scar and resistant to endocardial radiofrequency ablation, by left ventricular reconstruction with cryoablation. Li et al[34] conducted a retrospective investigation of 38 consecutive surgical epicardial VT ablation procedures and compared the results with those of a propensity-matched percutaneous epicardial access control group. Surgical epicardial access after heart surgery for VT ablation showed no statistical difference in long-term results in comparison to the percutaneous epicardial group[rx].

Recently, Berte et al[rx] presented the first animal survey utilizing a more potent cryoablation system that can generate larger, transmural ventricular lesions from both the endocardium and the epicardium. Surgical cryoablation in sheep had no acute macroscopic vascular or extracardiac damage and resulted in 100% successful lesions at necropsy[rx].

In some patients with non-ischemic cardiomyopathy and VT refractory to standard therapy or undergoing cardiac surgery, surgical ablation may be an alternative option for potentially reducing the burden of ICD shocks during long-term follow-up[rx]. Liang et al[rx] showed that detailed arrhythmogenic substrate in the electrophysiology lab before surgery, in conjunction with a direct scar and radiofrequency ablation lesions visualization in the operating room, is crucial for guiding surgical ablation.

Extracorporeal life support for refractory VT

Extracorporeal life support is a highly efficient bridging treatment in patients with refractory VT associated with cardiogenic shock[rx]. Extracorporeal life support allows the usage of negative inotropic antiarrhythmic drug therapy, leads to the weaning of catecholamine delivery, thus resolving the dangerous period of the catecholamine driven electrical storm[rx]. The utilization of extracorporeal life support maintains hemodynamic support during an ablation procedure, while mapping and induction of VT are commenced and provides sufficient vital organ perfusion in patients with refractory VT[rx]. Current literature suggests the usage of extracorporeal life support, as it has proven to be a safe, practical and efficient therapeutic solution when traditional treatments have failed[rx].

Steroid pulse therapy

Okabe et al[rx] successfully treated a patient with cardiac sarcoidosis associated with VT using steroid pulse therapy.