Uses Indications of Eluxadoline Tablet

Eluxadoline is a mu-opioid receptor agonist, kappa-opioid receptor agonist, and a delta-opioid receptor antagonist. Eluxadoline is used for diarrhea-predominant IBS because it reduces intestinal contractility and normalizes stress-induced acceleration of upper GI transit. Antagonistic activity at the delta receptor minimizes the constipating effect usually seen by mu-opioid receptor agonists alone. Because of its limited systemic bioavailability, there may be fewer side effects associated with the use of eluxadoline in comparison with other therapies used to treat diarrhea-predominant IBS.

• For the treatment of irritable bowel syndrome with diarrhea (IBS-D).
• Truberzi is indicated in adults for the treatment of irritable bowel syndrome with diarrhea (IBS D).
• Eluxadoline is a mixed opioid receptor agonist (mu) and antagonist (delta) that is used to treat diarrhea-predominant irritable bowel disease.
• Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
• Diarrhoea Predominant Irritable Bowel Syndrome

Contraindications of Eluxadoline

This drug is contraindicated in case of having

• Blockage of the gallbladder or a sphincter of Oddi problem
• Problems with alcohol abuse
• Pancreatitis
• Liver problems
• Chronic or severe constipation
• are allergic to eluxadoline or any ingredients of the medication
• have or may have a biliary duct blockage
• do not have a gallbladder
• consume more than 3 alcoholic drinks daily
• are alcoholic, have an alcohol addiction, or abuse alcohol
• have a history of inflammation of the pancreas (pancreatitis)
• have decreased liver function
• have a history of chronic or severe constipation
• have or have had an obstruction of the digestive tract

Dosage of Eluxadoline

Strengths: 75 mg; 100 mg

Irritable Bowel Syndrome

• Usual dose: 100 mg orally twice a day
• Dose should be reduced to 75 mg orally twice a day for patients unable to tolerate usual dose.
• If severe constipation develops, this drug should be discontinued.

Side Effects of Eluxadoline

Most Common 

• Bloating
• symptoms of pancreatitis (e.g., abdominal pain, nausea, vomiting)
• new or worsening belly pain, nausea, vomiting, or sudden pain in the upper right abdomen)
• constipation
• darkened urine
• fast heartbeat
• fever
• indigestion
• loss of appetite
• nausea
• pains in the stomach, side, or abdomen, possibly radiating to the back
• vomiting
• yellow eyes or skin

Rare

• Cough
• difficulty swallowing
• Body aches or pain
• cough producing mucus
• difficulty with breathing
• ear congestion
• excess air or gas in the stomach or bowels
• dizziness
• hives, itching, skin rash
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• tightness in the chest
• unusual tiredness or weakness