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Eperisone HCl; Indications, Dosage, Side Effect, Interactions, Pregnancy

Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex. It is not approved for use in the United States, but is available in other countries like India, South Korea, and Bangladesh.

Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex.

Mechanisms of Action of Eperisone

Mechanisms of action of eperisone on isolated dog saphenous arteries and veins. Eperisonerelaxed saphenous arteries and veins previously contracted with norepinephrine, serotonin, acetylcholine, K+, or Ba2+; but in contrast, it produced contractions in the blood vessels contracted with prostaglandin (PG) F2 alpha.of eperisone on isolated dog saphenous arteries and veins. Eperisonerelaxed saphenous arteries and veins previously contracted with norepinephrine, serotonin, acetylcholine, K+, or Ba2+; but in contrast, it produced contractions in the blood vessels contracted with prostaglandin (PG) F2 alpha.

Indications of Eperisone

Spastic paralysis in conditions such as cerebrovascular disease
Spastic spinal paralysis
Cervical spondylosis
Postoperative sequelae (including from cerebrospinal tumour)
Sequelae to trauma (e.g. spinal trauma or head injury)
Amyotrophic lateral sclerosis
Cerebral palsy
Spinocerebellar degeneration
Spinal vascular diseases and other encephalomyelopathies
Cervical syndrome, periarthritis of the shoulder, and lumbago
Skeletal muscle relaxation
Relaxation of hypertonic skeletal muscles
Improves intramuscular blood flow
Suppression of spinal reflex potentials
Reduction of muscle spindle sensitivity via motor neurons
Vasodilatation and augmentation of blood flow
Analgesic action and inhibition of the pain reflex in the spinal cord

Contra Indications of Eperisone

Eperisone is contraindicated in patients with known hypersensitivity to the drug.Side effects: ‘very rare’ excessive relaxation, stomachache, nausea, vertigo, anorexia, drowsiness, skin rashes, diarrhoea, vomiting, indigestion, GI disturbances, insomnia, headache, constipation etc.

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Dosage of Eperisone

Strengths : 50 mg, 100 mg

Dosage‎: ‎Adult: PO 50 mg 3 times/day

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
50 mg	50 (50)	8 hourly	PO
Paedriatic Dosage (20kg)
				Not recommended in this age group
Neonatal Dosage (3kg)
				Not recommended in this age group

Side Effects of Eperisone

The most common

Acid or sour stomach
Stomach discomfort and cramps
Dizziness
Skin rash
Nausea and vomiting
Elevated liver enzymes
Blood clotting disorders
Stevens-Johnson Syndrome
Central Nervous System : Weakness, dizziness, sleeplessness, drowsiness, numbness or trembling in the extremities.
Miscellaneous : Liver, kidney dysfunction; changes in blood counts, skin rashes, itching, gastrointestinal disturbances and urinary disorders.

Rare

Weakness, dizziness, insomnia, drowsiness, numbness or trembling in the extremities, hepatic and renal dysfunction, haematological changes, skin rashes, itching, GI disturbances, urinary disorders, Rarely, shock.

Drug Interactions of Eperisone

Whenever you take more than one medicine, or mix it with certain foods or beverages, you’re at risk of a drug interaction.

Interaction with Alcohol

Consumption of alcohol can cause severe and potentially irreversible side effects on the liver when taken along with this medicine.

Instructions

You should avoid consuming alcohol while taking myonal 50 MG Tablet. Symptoms like fever, chills, rashes, joint pain and swelling, excessive weakness, nausea should be immediately reported to the doctor.

Interaction with Medicine

Other adverse reactions

	5%> ≥0.1%	<0.1%	Incidence unknown
Hepatic		Elevation of AST (GOT), ALT(GPT) and Al-P, etc.
Renal		Proteinuria and Elevation of BUN etc.
Hematologic		Anemia
Hypersensitivity	Rash	Pruritus	erythema exudativum multiforme
Psychoneurologic	Sleepiness, insomnia, headache and numbness in the extremities	Stiffness and tremor in the extremities
Gastrointestinal	Nausea/vomiting, anorexia, stomach discomfort, abdominal pain, diarrhea, constipation and thirst	Stomatitis and tremor in the extremities
Urinary		Urinary retention, urinary incontinence and the feeling of residual urine

Pregnancy & Lactation

Use During Pregnancy eperisone HCl should only be used in pregnant women or women suspected of being pregnant if the expected therapeutic benefits are evaluated to outweigh the possible risk of treatment. The safety of eperisone HCl in pregnant women has not been established.
Use During Lactation It is advisable to avoid the administration of eperisone HCl to nursing mothers. When eperisone HCl must be used, breast feeding should be discontinued during treatment.