Category: Health A – Z

Endometrial metaplasias are of two types, epithelial metaplasia which is commonly encountered and stromal metaplasia, unusually seen. This includes formation within endometrial stroma, islands of smooth muscle, cartilage, and bone. Endometrial stromal (cartilaginous) metaplasias are conditions frequently overlooked and misdiagnosed. Hence, a careful clinical and histopathological examination is required to avoid the misinterpretation of non-tumor…

Ewing sarcoma (ES) is a highly malignant tumor composed of small round cells. The origin of this tumor was unclear until recently, when electron microscopic and immunohistochemical analyses suggested that it is of neurogenic origin [1–3]. ES tumors often express a balanced translocation involving the EWS gene on chromosome 22 and a member of the…

Angiosarcoma (AS) comprises 1% of all soft-tissue sarcoma (STS), which are themselves a rare malignancy. They arise from lymphatic or vascular endothelial cells and are ‘high-grade’ by definition, which demonstrates their aggressive behavior.[rx] Although AS can occur in any part of the body, it most commonly presents as a cutaneous disease in elderly white men or…

Sarcoma/Soft tissue sarcomas (STS) are a group of more than 60 different neoplasms that can originate from any location throughout the human body, and they can affect individuals at the extremes of age. From skeletal muscle, adipose tissue, blood, and lymphatics to connective tissue and peripheral nerves; these neoplasms can span a range of clinical…

Osteogenic sarcoma (osteosarcoma) is the most common primary tumor of the bone, found most commonly in the extremities, with a bimodal age distribution.[1] Approximately 75% of cases present before the age of 25 years and are majorly primary (without attributing risk factor). A late peak is seen after the age of 50 years (peaking at 70 years),…

Login     Login Or  Create Account /Signup I am malefemale My Age -Select -Select-18192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869707172737475767778798081828384858687888990919293949596979899100– City/ZIP E-mail Password Sign Up

Plasmacytoma is a plasma cell dyscrasia in which a plasma cell tumour grows within soft tissue or within the axial skeleton. The International Myeloma Working Group lists three types: solitary plasmacytoma of bone (SPB); extramedullary plasmacytoma (EP), and multiple plasmacytomas that are either primary or recurrent.[rx] The most common of these is SPB, accounting for 3–5% of all plasma cell malignancies.[rx] SPBs occur as lytic lesions within the axial skeleton…

Waldenström Macroglobulinemia (WM) is a low-grade B-cell clonal disorder characterized by lymphoplasmacytic bone marrow involvement associated with monoclonal immunoglobulin M (IgM). Although WM remains to be an incurable disease with a heterogeneous clinical course, the recent discovery of mutations in the MYD88 and CXCR4 genes further enhanced our understanding of its pathogenesis. Development of new…

Splenic Marginal Zone B-cell Lymphoma/Splenic Marginal Zone Lymphoma (also known as splenic marginal zone B-cell lymphoma) is one of a family of indolent B-cell lymphomas that remain incompletely characterized. These lymphomas can be globally classified into mucosa-associated lymphatic tissue (MALT) lymphoma, also known as extranodal marginal zone lymphoma, and the nonmucosa-associated lymphatic tissue (non-MALT) marginal…

Childhood Leukemia is a leukemia that occurs in a child and is a type of childhood cancer. Childhood leukemia is the most common childhood cancer, accounting for 29% of cancers in children aged 0–14 in 2018.[1] There are multiple forms of leukemia that occur in children, the most common being acute lymphoblastic leukemia (ALL) followed by acute myeloid leukemia (AML).[2] Survival rates…

Acute Granulocytic Leukemia/Acute myelocytic leukemia (AML) is a disorder of uncontrolled proliferation of undifferentiated myeloid precursor cells. This leads to the accumulation of immature myeloid cells, myeloblasts, in the bone marrow, and usually their presence in the peripheral blood. Acute leukemias are differentiated from chronic leukemias by the predominance of the neoplastic, clonal blast as…

Eosinophilic Cellulitis/Wells Syndrome is characterized clinically by an acute dermatitis resembling cellulitis and histopathologically by dermal eosinophilic infiltration. Wells syndrome is a rare eosinophilic disorder that primarily affects the skin. Affected people typically develop a skin rash that is often preceded by itching or burning skin. The rash consists of raised, red, swollen areas that may be warm to the touch.…