Tamsulosin; Uses, Dosage, Side Effects, Interactions

Tamsulosin; Uses, Dosage, Side Effects, Interactions

Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B, and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.

Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate

Mechanism of Action of Tamsulosin

Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B, and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate, and thus decreases urinary outflow resistance in men. Studies show that tamsulosin has about 12 times greater affinity for alpha-1 adrenergic receptors in the prostate than those in the aorta, which may result in a reduced incidence of adverse cardiovascular effects.

Indications of Tamsulosin

  • Benign Prostatic Hyperplasia
  • Urinary Tract Stones
  • Overactive Bladder
  • Bladder Outlet Obstruction
  • Ureteral Calculus
  • Treatment for acute urinary retention.
  • Used in the treatment of signs and symptoms of benign prostatic hyperplasia (reduction in urinary obstruction and relief of associated manifestations such as hesitancy, terminal dribbling of urine, interrupted or weak stream
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Contra-Indications of Tamsulosin

Dosages of tamsulosin

  • Strengths: 0.4 mg

Benign Prostatic Hyperplasia

Initial Dose

  • 0.4 mg orally once a day

Maximum Dose

  • 0.8 mg orally once a day

For patients who do not respond to the 0.4 mg dose after 2 to 4 weeks, the dose may be increased to 0.8 mg orally once a day

Side Effects of Tamsulosin

The most common

Less common

Rare

Rare

Drug Interaction of Tamsulosin

Tamsulosin hydrochloride may interact with following drugs, supplements &  change the efficacy of drugs

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Pregnancy & Lactation Tamsulosin

FDA Pregnancy Category B

Pregnancy

Tamsulosin is not recommended for women, including pregnant women.

Lactation

Tamsulosin is not recommended for women, in breastfeeding-feeding women.

References

  1. https://pubchem.ncbi.nlm.nih.gov

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