Roxatidine; Uses, Dosage, Side Effects, Interactions

Roxatidine; Uses, Dosage, Side Effects, Interactions

Roxatidine is a specific and competitive histamine H2 receptor antagonist drug that is used to treat gastric ulcers, Zollinger–Ellison syndrome, erosive esophagitis, gastro-oesophageal reflux disease, and gastritis. Pharmacodynamic studies showed that 150 mg of roxatidine acetate were optimal in suppressing gastric acid secretion and that a single bedtime dose of 150 mg was more effective than a dose of 75 mg twice daily in terms of inhibiting nocturnal acid secretion.

Mechanism of Action of Roxatidine

The H2 antagonists are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked.

Indications of Roxatidine

Contra-Indications of Roxatidine

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Dosage of Roxatidine

Strengths:  75 mg; 150 mg; 300 mg;

Duodenal Ulcer

  • Initial: 300 mg orally once a day at bedtime, or alternatively may use 150 mg orally twice a day.
  • Maintenance: 150 mg orally once a day at bedtime.

Duodenal Ulcer Prophylaxis

  • 150 mg orally once a day at bedtime.

Gastric Ulcer

  • 300 mg orally once a day at bedtime, or alternatively may use 150 mg orally twice a day.

Side Effects of Roxatidine

The most common

More common

Rare

Drug Interactions of Roxatidine

Roxatidine may interact with following drugs, supplements, & may change the efficacy of the drug

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Pregnancy Catagory

FDA Pregnancy Category N

Pregnancy

The safety of this medication for use during pregnancy has not been established. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

You should not take roxatidine if you are breastfeeding. It may be excreted in your breast milk and may harm your nursing child.

References

Roxatidine

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