Pefloxacin; Uses, Dosage, Side Effects, Interactions, Pregnanc

Pefloxacin; Uses, Dosage, Side Effects, Interactions, Pregnanc

Pefloxacin is a fluoroquinolone antibiotic with broad-spectrum antimicrobial activity. Pefloxacin inhibits the activity of microbial DNA gyrase and topoisomerase IV. This disrupts DNA replication and prevents cell division.
Pefloxacin is only found in individuals that have used or taken this drug. It is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria. [PubChem]The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.

Mechanism of Action of Pefloxacin

The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.

Indications of Pefloxacin

  • For the treatment of uncomplicated gonococcal urethritis in males and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract.
  • Uncomplicated gonococcal urethritis in males.[2]
  • Bacterial infections in the gastrointestinal system.[2]
  • Genitourinary tract infections.[2]
  • Gonorrhea. however, this indication is no longer effective due to bacterial resistance.[3]
  • Pefloxacin has been increasingly used as a veterinary medicine to treat microbial infections.[4]
  • Urinary tract infections
  • Inflammatory vaginal discharge
  • Ulceration of the lymph nodes
  • Bacterial infection of the stomach
  • Bacterial infection of intestines
  • Typhoid
  • Bone and respiratory infections
  • Inflammation of the meninges
  • Inflammation of the conjunctiva of the eye
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Contra-Indications of Pefloxacin

  • Information not Available

Side Effects of Pefloxacin

Most common

More common

Rare

Drug Interactions of Pefloxacin

Pefloxacin may interact with following drugs, supplements, & may change the efficacy of drugs

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Pregnancy Category

FDA Pregnancy Category – N (not known)

References

Pefloxacin

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