Mebeverine; Uses, Dosage, Side Effects, Interactions, Pregnancy

Mebeverine; Uses, Dosage, Side Effects, Interactions, Pregnancy

Mebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms. Mebeverine is a drug used to alleviate some of the symptoms of irritable bowel syndrome. It works by relaxing the muscles in and around the gut. It is a direct relaxant of gut (intestinal) muscle and is sometimes known as an antispasmodic drug. It is used to relax the muscles of the intestine and to treat symptoms of irritable bowel syndrome and related conditions.

Mechanism of Action of Mebeverine

Mebeverine is an anticholinergic but its mechanism of action is not known; it appears to work directly on smooth muscle within the gastrointestinal tract and may have an anesthetic effect, may affect calcium channels, and may affect muscarinic receptors. It is metabolized mostly by esterases, and almost completely. The metabolites are excreted in urine.

Indications of Mebeverine

Contra-Indications of Mebeverine

  • Hypersensitivity

Dosage of Mebeverine

  • Strengths: 135 mg

 PO GI tract spasm

  • Irritable bowel syndrome 135 mg tTID may reduce gradually after several wk when the desired effect has been obtained; 100 mg tid has also been used.
  • As modified-release cap: 200 mg bid.
You Might Also Like   Ceforanide; Uses, Dosage, Side Effects, Interactions

Gastrointestinal tract spasm, Irritable bowel syndrome

  • 135 mg tid, may reduce gradually after several wk when the desired effect has been obtained;
  • 100 mg tid has also been used. As modified-release cap: 200 mg bid.

Side Effects

The most common

More common

Drugs Interactions of Mebeverine

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: none known.

Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of none has known

This information does not contain all possible interactions. Therefore, before using mebeverine, tell your doctor or pharmacist of all the products you use.

Pregnancy & Lactation of Mebeverine

FDA Pregnancy Category – N (Not Assigned)

Pregnancy

Several studies have suggested an increased risk of congenital malformations associated with the use of minor tranquilizers (i.e., chlordiazepoxide, diazepam, meprobamate) during the first trimester of pregnancy. There are no adequate studies in pregnant women.

References

 

Mebeverine

About the author

Translate »