Levamlodipine; Uses, Dosage, Side Effects, Interactions

Levamlodipine; Uses, Dosage, Side Effects, Interactions

Levamlodipine also was known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive and anti-anginal medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication is currently marketed in Russia and India. The names S-amlodipine and levamlodipine may be used interchangeably as both substances are the same, however, with differing nomenclature. As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine as the active moiety possesses therapeutic activity

Levamlodipine (INN), also known as levoamlodipine or S-amlodipine is a pharmacologically active enantiomer of amlodipine. It is a pharmacologically active enantiomer of amlodipine, an antihypertensive and anti-anginal medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. Amlodipine belongs to the dihydropyridine group of calcium channel blocker used as an antihypertensive and antianginal agent.

Mechanism of Action Levamlodipine

Levamlodipine blocks the transmembrane influx of calcium into the vascular and cardiac smooth muscles resulting in vasodilation and a subsequent decrease in blood pressure. This drug is an allosteric modulator and acts on the L-type calcium channels. It exerts the same mechanism of action, differing only in its form as an enantiomer.

Levamlodipine blocks the transmembrane influx of calcium into the vascular and cardiac smooth muscles resulting in vasodilation and a subsequent decrease in blood pressure. This drug is an allosteric modulator and acts on the _L-type calcium channels_. It exerts the same mechanism of action, differing only in its form as an enantiomer [L1485]. The exact mechanisms by which levamlodipine relieves angina have not been fully understood, but the mechanism is thought to be twofold. Firstly, the modulation of calcium influx caused by levamlodipine leads to decreased peripheral resistance by arteriolar vasodilatation and subsequent reduction in oxygen requirement for cardiac muscle. Secondly, a decrease in coronary vascular resistance which can lead to an increase in coronary blood flow. Negative inotropic effects can be demonstrated in vitro but such effects have not been observed in live animals at therapeutic doses [L1485]. Receptor binding studies of amlodipine have shown that out of the two enantiomer forms, only the (S) enantiomer of amlodipine (levamlodipine) binds to and blocks L-type calcium channels. The (R) enantiomer has no activity on these channels

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Receptor binding studies of amlodipine have shown that out of the two enantiomer forms, only the (S) enantiomer of amlodipine (levamlodipine) binds to and blocks L-type calcium channels. The (R) enantiomer has no activity on these channels .

Indications of Levamlodipine

Contra-Indications of Levamlodipine

Dodage of Levamlodipine

Strengths: 1.25mg,2.5mg ,5mg

Hypertension

  • The recommended starting dose is 5 mg once daily, alone or in combination with other agents.
  • It may be increased up to 40 mg once daily, if needed. Heart failure: The recommended starting dose is 1.25 mg once daily. May double dose 1-2 weekly up to a max of 10 mg once daily.

Side Effects of Levamlodipine

The most common 

More common

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Rare

Drug Interactions of Levamlodipine

Levamlodipine  may interact with the following drugs, suppliments, & may change the efficacy of the drug

Pregnancy Category

FDA Pregnancy Category D

Pregnancy

This medication should not be taken by women who are or may become pregnant, as levamlodipine may cause harm to the developing baby if it is taken by the mother during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

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Lactation

This medication should not be taken by women who are breast-feeding.T he safety and effectiveness of using this medication have not been established for children.

References

  1. Levamlodipine

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