Dapoxetine, Uses, Dosage, Side Effects, Interactions, Pregnancy

Dapoxetine, Uses, Dosage, Side Effects, Interactions, Pregnancy

Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. Alza submitted an NDA to the FDA for dapoxetine for the treatment of premature ejaculation in December 2004. In October 2005, the company received an FDA Non-Approvable letter from the FDA, at which time they planned to work with regulators to address outstanding questions

Mechanism of Action of Dapoxetine

The drug’s mechanism of action is thought to be related to the inhibition of neuronal reuptake of serotonin and subsequent potentiation of serotonin activity. The central ejaculatory neural circuit comprises spinal and cerebral areas that form a highly interconnected network. The sympathetic, parasympathetic, and somatic spinal centers, under the influence of sensory genital and cerebral stimuli, integrated and processed at the spinal cord level, act in synergy to command physiologic events occurring during ejaculation. Experimental evidence indicates that serotonin (5-HT), throughout brain descending pathways, exerts an inhibitory role on ejaculation. To date, three 5-HT receptor subtypes (5-HT(1A), 5-HT(1B), and 5-HT(2C)) have been postulated to mediate 5-HT’s modulating activity on ejaculation.

Indications of Dapoxetine

An intravaginal ejaculatory latency time (IELT) of less than two minutes

Contra-Indications of Dapoxetine

Dosage of Dapoxetine

Strengths: 30 mg, 60 mg

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Erectile Dysfunction

  • Dosage 30 mg one to three hours before planned sexual activity. Dapoxetine should only be taken once a day. In the case of inefficacy without side effects, the dosage may be increased to 60 mg.

Side Effects of Dapoxetine

The most common

Common

Rare

Drug Interactions of Dapoxetine

Dapoxetine may interact with following drugs, supplements, & may change the efficacy of drugs

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Pregnancy & Lactation of Dapoxetine

Not Prescribe for women

References

 

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