Cefotiam; Indications, Contra indications, Dosage, Side effects, Interaction

Cefotiam; Indications, Contra indications, Dosage, Side effects, Interaction

Cefotiam Hydrochloride is the hydrochloride salt form of cefotiam, a second-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Mechanism of action of Cefotiam

The bactericidal activity of cefotiam results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefotiam is a third generation beta-lactam cephalosporin antibiotic. It has broad-spectrum activity against Gram-positive and Gram-negative bacteria. It does not have activity against Pseudomonas aeruginosa. Cefotiam works by inhibiting bacterial cell wall biosynthesis. Cefotiam is a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Indications of Cefotiam

For the treatment of infections caused by susceptible organisms.

  • For the treatment of serious infections caused by susceptible strains microorganisms.
  • Lower respiratory tract infections, including pneumonia and lung abscess,s
  •  Urinary tract infections caused by Escherichia coli, Klebsiella species,
  • Intra-abdominal infections, including peritonitis and intra-abdominal abscess,
  • Gynecological infections, including endometritis, pelvic cellulitis, and pelvic inflammatory

Contra-Indications of Cefotiam

  • Liver problems
  • Interstitial nephritis
  • Subacute cutaneous lupus erythematosus
  • Systemic lupus erythematosus

Allergies cephalosporins & beta-lactams

Side Effects of Cefotiam

The most common

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More common

Rare

Drug Interactions of Cefotiam

Cefotiam may interact with the following drugs, supplements, & may change the efficacy of drugs

Pregnancy Catagory of Cefotiam

FDA Pregnancy Category  B

Pregnancy

It is not known if cefotiam is safe for use by pregnant women. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

This medication may pass into breast milk. If you are a breastfeeding mother and are taking cefotiam it may affect your baby. Talk to your doctor about whether you should continue breastfeeding.It is not known if cefotiam is safe for children under 6 months of age.

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References

  1. Literature references related to scientific contents from Springer Nature journals and books. Read more …
  2. https://pubchem.ncbi.nlm.nih.gov

Cefotiam

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