Cefonicid; Uses, Indications, Dosage, Side Effects, Interaction

Cefonicid; Uses, Indications, Dosage, Side Effects, Interaction

Cefonicid is a second-generation semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
Cefonicid binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Mechanism of Action of Cefonicid

Cefonicid, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.

Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Indications of Cefonicid

For the treatment of serious infections caused by susceptible strains microorganisms.

  • Lower respiratory tract infections, including pneumonia and lung abscess,s
  •  Urinary tract infections caused by Escherichia coli, Klebsiella species,
  • Intra-abdominal infections, including peritonitis and intra-abdominal abscess,
  • Gynecological infections, including endometritis, pelvic cellulitis, and pelvic inflammatory disease caused
  • Bacterial Infections
  • Bloodstream Infections
  • Bone and Joint Infections
  • Aspiration Pneumonia Cesarean Section
  • Bronchitis
  • Tonsillitis
  • Endometritis
  • Flu caused by Influenza
  • Infected animal bite
  • Intra-Abdominal Infections
  • Lower respiratory tract infection bacterial
  • Peritonitis
  • Pneumonia
  • Skin and Subcutaneous Tissue Bacterial Infections
  • Skin and skin structure infections caused by Staphylococcus aureus

Contra-Indications of  Cefonicid

  • Clostridium difficile infection
  • Decrease in the blood-clotting protein prothrombin
  • Severe renal impairment
  • Inadequate vitamin K
  • Hemolytic anemia
  • Liver problems
  • Interstitial nephritis
  • Subacute cutaneous lupus erythematosus
  • Systemic lupus erythematosus
  • Allergies cephalosporins & beta-lactams
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Side Effects of Cefonicid

The most common

More common

Rare

Drug Interactions of Cefonicid

Cefonicid may interact with the following drugs, supplements, & may change the efficacy of drugs

Pregnancy Catagory of Cefonicid

FDA Pregnancy Category  B

Pregnancy

It is not known if cefonicid is safe for use by pregnant women. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

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Lactation

This medication may pass into breast milk. If you are a breastfeeding mother and are taking cefonicid it may affect your baby. Talk to your doctor about whether you should continue breastfeeding. It is not known if cefonicid is safe for children under 6 months of age.

References

  1. Cefonicid

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