Cefmetazole; Uses, Dosage, Side Effects, Interactions

Cefmetazole; Uses, Dosage, Side Effects, Interactions

Cefmetazole sodium is a semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date, no severe side effects have been noted.
Cefmetazole Sodium is the sodium salt form of cefmetazole, a second-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefmetazole binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Mechanism of Action of Cefmetazole

The bactericidal activity of cefmetazole results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefmetazole Sodium is the sodium salt form of cefmetazole, a second-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefmetazole binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Cefmetazole is a second-generation cephalosporin. The cephalosporins are bactericidal drugs with both gram-positive and gram-negative activity. They inhibit bacterial cell wall synthesis in a way similar to the penicillins. Cefmetazole is more active than 1st-generation cephalosporins against indole-positive ProteusSerratia, anaerobic gram-negative bacilli (including B. fragilis), and some E. coliKlebsiella, and P. mirabilis, but is less active than cefoxitin or cefotetan against most gram-negative bacilli.
Cefmetazole is a second-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefmetazole binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Indications of Cefmetazole

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Contra-Indications of Cefmetazole

  • Clostridium difficile infection
  • The decrease in the Blood-Clotting Protein Prothrombin
  • severe renal impairment
  • Liver problems
  • Interstitial Nephritis
  • Subacute cutaneous lupus erythematosus
  • Systemic Lupus Erythematosus
  • Allergies cephalosporins & beta-lactams

Dosage of Cefmetazole

I.V/IM

Prophylaxis of anaerobic and mixed bacterial infections; 

  • 0.5-1 g 12 hourly. Severe infections: 3-4 g/day, given in divided doses 6-8 hr.

Prophylaxis of anaerobic and mixed bacterial infections 

I.V

  • 0.5-1 g every 12 hr via IM inj or slow IV inj over 3-5 minutes.
  • Severe infections: 3-4 g daily, given in divided doses every 6-8 hr. The dose can also be given via IV infusion over 10-60 minutes.

Side Effects of Cefmetazole

The most common

More common

Rare

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Drug Interactions

Cefmetazole may interact with following drugs, supplements, & may change the efficacy of drugs

Pregnancy Catagory of Cefmetazole

FDA Pregnancy Category  B

Pregnancy

There are no well-done studies that have been done in humans with Cefmetazole. But in animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.

Lactation

In animal studies, pregnant animals were given Cefmetazole, and some babies had problems. But in human studies, pregnant women were given this medication and their babies did not have any problems related to this medication.

References

Cefmetazole

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