Cefetamet; Mechanism, Uses, Dosage, Side effects, Interaction, Pregnancy

Cefetamet; Mechanism, Uses, Dosage, Side effects, Interaction, Pregnancy

Cefetamet is a semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity. Cefetamet binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Mechanism of Action of Cefetamet

The bactericidal activity of cefetamet results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefetamet highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. Cefetamet is a semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity. Cefetamet binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Indications of Cefetamet

For the treatment of infections due to susceptible strains of microorganisms.

  • Intra-Abdominal
  • For the treatment of serious infections caused by susceptible strains microorganisms.
  • Lower respiratory tract infections, including pneumonia and lung abscess,s
  •  Urinary tract infections caused by Escherichia coli, Klebsiella species,
  • Intra-abdominal infections, including peritonitis and intra-abdominal abscess,
  • Gynecological infections, including endometritis, pelvic cellulitis, and pelvic inflammatory disease caused
  • Bacterial Infections
  • Bloodstream Infections
  • Otitis media,
  • Sinusitis,
  • Pharyngotonsillitis,
  • Lower respiratory tract infections,
  • Acute bacterial exacerbation of chronic bronchitis,
  • Tracheobronchitis,
  • Pneumonia,
  • Urinary tract infections,
  • Gonococcal urethritis in men
  • Bone and Joint Infections
  • Aspiration Pneumonia Cesarean Section
  • Bronchitis
  • Tonsillitis
You Might Also Like   Colchicine - Uses, Dosage, Side Effects, Interactions

Contra-Indications of Cefetamet

  • Hemolytic anemia
  • Liver problems
  • Interstitial nephritis
  • Subacute cutaneous lupus erythematosus
  • Systemic lupus erythematosus
  • Allergies cephalosporins & beta-lactams

Dosage of Cefetamet

Strengths: 500 mg

Adult: 500 mg bid.

Side Effects of Cefetamet

The most common

More common

Rare

Drug Interactions of Cefetamet

Cefetamet may interact with the following drugs, supplements, & may change the efficacy of drugs

You Might Also Like   Prednisolone, Indications, Dosage, Side Effect, Interactions, Pregnancy

Pregnancy Catagory of Cefetamet

FDA Pregnancy Category  B

Pregnancy

It is not known if Cefetamet is safe for use by pregnant women. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

This medication may pass into breast milk. If you are a breastfeeding mother and are taking cefetamet it may affect your baby. Talk to your doctor about whether you should continue breastfeeding. It is not known if cefetamet is safe for children under 6 months of age.

References

  1. https://pubchem.ncbi.nlm.nih.gov

Cefetamet

About the author

Translate »