Cefamandole; Uses, Dosage, Side Effects, Interactions

Cefamandole; Uses, Dosage, Side Effects, Interactions

Cefamandole is a second-generation cephalosporin antibiotic with bactericidal activity. Cefamandole is active against Haemophilus and gram-negative bacilli susceptible to other cephalosporins. It is also active against many strains resistant to other cephalosporins, such as Enterobacter species and indole-positive Proteus species.
Cefamandole is only found in individuals that have used or taken this drug. It is a broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally. Cefamandole is no longer available in the United States. Like all beta-lactam antibiotics, cefamandole binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefamandole interferes with an autolysin inhibitor.

Mechanism of Action of Cefamandole

Like all beta-lactam antibiotics, cefamandole binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefamandole interferes with an autolysin inhibitor.The bactericidal action of cefamandole results from inhibition of cell-wall synthesis. Cephalosporins have in vitro activity against a wide range of gram-positive and gram-negative organisms.

Indications of Cefamandole

  • Pneumonia
  • Skin or soft tissue infection
  • Surgical prophylaxis
  • Urinary tract infection
  • Aspiration pneumonia cesarean section
  • Bronchitis
  • Tonsillitis
  • Endometritis
  • Flu caused by Influenza
  • Infected animal bite
  • Intra-Abdominal Infections
  • Lower respiratory tract infection bacterial
  • Peritonitis
  • Skin and Subcutaneous Tissue Bacterial Infections
  • Skin and skin structure infections caused by Staphylococcus aureus
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Contra-Indications of Cefamandole

  • Clostridium difficile infection
  • The decrease in the blood-clotting protein prothrombin
  • Severe renal impairment
  • Inadequate vitamin K
  • Hemolytic anemia
  • Liver problems
  • Interstitial nephritis
  • Subacute cutaneous lupus erythematosus
  • Systemic lupus erythematosus
  • Allergies cephalosporins & beta-lactams

Dosage of Cefamandole

Strengths: 500 mg to 1 g

Pneumonia

  • The usual dosage range for cefamandole (cefamandole) e is 500 mg to 1 g every 4 to 8 hours.

Infections of skin structures

  • 500 mg every 6 hours is adequate.

Uncomplicated pneumonia,

  • 500 mg every 6 hours is adequate.

Uncomplicated urinary tract infections,

  • 500 mg every 8 hours is sufficient. In more
  • serious urinary tract infections, a dosage of 1 g every 8 hours may be needed.
  • In severe infections, 1-g doses may be given at 4 to 6-hour intervals.

In life-threatening infections or infections due to less susceptible organisms,

  • doses up to 2 g every 4 hours (ie, 12 g/day) may be needed.

Infants and Children

  • Administration of 50 to 100 mg/kg/ day in equally divided doses every 4 to 8 hours has been effective for most infections susceptible to (cefamandole).
  • This may be increased to a total daily dose of 150 mg/kg (not to exceed the maximum adult dose) for severe infections.

Side Effects

The most common

More common

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Rare

Drug Interactions of Cefamandole

Cefamandole may interact with the following drugs, supplements, & may change the efficacy of drugs

Pregnancy Catagory of Cefamandole

FDA Pregnancy Category  B

Pregnancy

There are no well-done studies that have been done in humans with Cefamandole. But in animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.

Lactation

In animal studies, pregnant animals were given Cefamandole, and some babies had problems. But in human studies, pregnant women were given this medication and their babies did not have any problems related to this medication.

References

Cefamandole

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