Nizatidine; Uses, Dosage, Side Effects, Interactions

Nizatidine; Uses, Dosage, Side Effects, Interactions

Nizatidine is a competitive and reversible histamine H2-receptor antagonist with antacid activity. Nizatidine inhibits the histamine H2-receptors located on the basolateral membrane of the gastric parietal cell, thereby reducing basal and nocturnal gastric acid secretion, resulting in a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli.
Nizatidine is a histamine type 2 receptor antagonist (H2 blocker) which is widely used for the treatment of acid-peptic disease and heartburn. Nizatidine has been linked to rare instances of clinically apparent acute liver injury.

Nizatidine also treats heartburn and erosive esophagitis caused by gastroesophageal reflux disease(GERD), a condition in which acid backs up from the stomach into the esophagus.

Mechanism of Action of Nizatidine

Nizatidine competes with histamine for binding at the H2-receptors on the gastric basolateral membrane of parietal cells. Competitive inhibition results in the reduction of basal and nocturnal gastric acid secretions. The drug also decreases the gastric acid response to stimuli such as food, caffeine, insulin, betazole, or pentagastrin. By inhibiting the action of histamine on stomach cells, nizatidine reduces stomach acid production. Nizatidine had no demonstrable antiandrogenic action. Full-dose therapy for the problems treated by nizatidine lasts no longer than 8 weeks. It has been demonstrated that treatment with a reduced dose of nizatidine is effective as maintenance therapy following healing of active duodenal ulcers.

Indications of Nizatidine

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Contra-Indications of Nizatidine

Dosage of Nizatidine

Strengths: 150 mg; 300 mg; 75 mg; 15 mg/mL

Duodenal Ulcer

  • Initial: 300 mg orally once a day at bedtime, or alternatively may use 150 mg orally twice a day.
  • Maintenance: 150 mg orally once a day at bedtime.

Duodenal Ulcer Prophylaxis

  • 150 mg orally once a day at bedtime.

Gastric Ulcer

  • 300 mg orally once a day at bedtime, or alternatively may use 150 mg orally twice a day.

Erosive Esophagitis

  • 150 mg twice daily.

Gastroesophageal Reflux Disease

  • 150 mg twice daily.


  • 75 mg orally once or twice a day, taken right before or up to 60 minutes before eating.

Pediatric Gastroesophageal Reflux Disease


  • Greater than 1 year (n=26): In mild to moderate reflux esophagitis: 10 mg/kg/day divided into two doses for 8 weeks.
  • Greater than or equal to 4 to 11 years (n=104): 6 mg/kg/day divided into two doses, one dose is given at 9 PM the night before surgery, and the other given at 6:30 AM the day of surgery.

Side Effects of Nizatidine

The most common

More common

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Drug Interactions of Nizatidine

Nizatidine may interact with the following drugs, supplements, & may change the efficacy ofthe drug

Pregnancy Catagory of Nizatidine

FDA Pregnancy Category B


The safety of this medication for use during pregnancy has not been established. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.


You should not take nizatidine if you are breastfeeding. It may be excreted in your breast milk and may harm your nursing child.


  1. Nizatidine



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