Anterior Tarsal Tunnel Syndrome – Symptoms, Treatment

Anterior Tarsal Tunnel Syndrome (ATTS) also known as deep peroneal nerve (DPN) entrapment, is a compression neuropathy of the DPN most commonly caused by the tight fascia band in the anterior ankle called the inferior extensor retinaculum. Two other anatomic locations of entrapment have been described and include deep to the extensor hallucis longus tendon overlying the talonavicular joint and deep to the extensor hallucis brevis muscle overlying the first and second tarsometatarsal joints.

The deep peroneal nerve is one of two terminal branches off the common peroneal nerve (CPN). The DPN bifurcates from the CPN in the anterior compartment of the lower leg and travels along the interosseous membrane. Just proximal to the ankle joint, the DPN courses between the extensor hallucis longus tendon and the extensor digitorum longus tendon. It then divides into the medial and lateral terminal branches. The EDB and EHB muscles are innervated by the lateral terminal branch of the DPN while the medial branch runs beside the dorsalis pedis artery in the dorsal foot and is purely sensory providing innervation to the first webspace.  In the anterior leg, the DPN provides motor innervation to the tibialis anterior (TA), extensor digitorum longus (EDL), peroneus tertius, and extensor hallucis longus (EHL) muscles.

The anterior tarsal tunnel is a fibro-osseous tunnel along the anterior ankle in which the borders include the inferior extensor retinaculum (superficially/roof), medial malleolus (medially), lateral malleolus (laterally), and the talonavicular joint capsule (deep/floor). Contents of the anterior tarsal tunnel include the dorsalis pedis artery/vein, deep peroneal nerve, tibialis anterior tendon, extensor hallucis longus tendon, extensor digitorum longus tendon, and peroneus tertius.

The common peroneal nerve receives contributions from the L4 through S2 nerve roots.

Symptoms of tarsal tunnel syndrome may include the following:

• Motor dysfunction as a result of atrophy
• Loss of pain
• Gait abnormality

Causes of Anterior Tarsal Tunnel Syndrome

Anterior tarsal tunnel syndrome is directly related to compression or entrapment of the deep peroneal nerve.[rx][rx][rx][rx][rx]The DPN most commonly becomes entrapped beneath the inferior extensor retinaculum secondary to acute trauma or repetitive micro-trauma, however other causes have also been reported[rx][rx][rx][rx][rx]:

• Surrounding space-occupying lesions such as a ganglion cyst, intraneural ganglion, and venous engorgement of the anterior tibial veins[rx][rx][rx]
• Osteophytes (bony overgrowth) of the metatarsals, talus, cuboid or navicular bones
• Compression by an accessory bone (os intermetatarseum)
• Hypertrophied extensor hallucis brevis muscle in athletes
• Irritation from extensor hallucis brevis tendon
• Compression from external sources such as tight-fitting shoes, athletic gear, or military equipment/boots
• Chronic prolonged stretching of the DPN or extreme plantar flexion of the ankle such as dancing, soccer, diving, Islamic Namaz praying
• Traction injury from ankle sprains or chronic ankle instability

Pathophysiology

Anterior tarsal tunnel syndrome results from the compression of the deep peroneal nerve beneath the inferior extensor retinaculum in the anterior ankle or one of its two terminal branches more distally in the foot. Trauma, tight-fitting shoe gear, or abnormal biomechanics may be contributing factors. Systemic/metabolic risk factors have not been identified as ATTS is typically due to local factors (local edema/compression), however theoretically, any disease process that induces systemic inflammation may contribute such as diabetes mellitus or rheumatoid arthritis.

Increased endoneurial fluid leading to intraneural microvascular congestion is the currently understood mechanism of compression-related nerve injuries. Continued damage can result in infarction and fibrosis of the nerve.

Diagnosis of Anterior Tarsal Tunnel Syndrome

History and Physical

A detailed patient history and clinical examination are the most important factors for an accurate diagnosis of ATTS.

Patients will typically complain of sharp shooting pain, numbness, or tingling along the distribution of the DPN or its terminal branches. Symptoms are typically intermittent and exacerbated by physical activity and alleviated by rest and elevated. The most common location of symptoms is the dorsal forefoot, more specifically the distal dorsal first webspace. The patient may recall a history of acute trauma (ankle sprain or hyper-plantar flexion injury) or repetitive microtrauma (runner or military trainee). On physical exam, repetitive percussion of the DPN may reproduce radiating paresthesias in the distal (Tinnel sign) or proximal (Valleix sign) directions. Palpation of the ankle may reveal edema or a space-occupying lesion (varicose vein or ganglion), while palpation of the foot may reveal palpable dorsal osteophytes (bone spurs). Extreme active or passive plantar flexion of the ankle may reproduce the patients’ symptoms due to a stretching/compression of the nerve. A pes cavus (high arch) foot type can be present on the exam, which can contribute to dorsal compressive forces and abnormal fitting of shoe-gear.

A full lower extremity musculoskeletal and neurologic exam should be performed, including muscle strength, vibratory, light touch, temperature, and two-point discrimination exams.

In a small case series of 13 patients, Yasin et al. reported that Tinel sign was positive in 100% of patients, and a palpable bulge in anterior ankle or foot was present in 92% of ATT’s cases.[rx]

Evaluation

There is no specific test to diagnose anterior tarsal tunnel syndrome, and diagnosis is primarily from a comprehensive history and physical examination with additional imaging as needed based on physician preference.

Blood work to rule out diabetes should be done. Some men with reactive arthritis may develop this disorder and be positive for HLA B27. In addition, systemic arthritic disorders should be ruled out by ordering ESR, antinuclear antibody, and rheumatoid factor.

Weight-bearing radiographs of the foot and ankle are a simple, inexpensive, and readily available test that can aid in identifying overall foot-type (pes cavus) or bone spurs that may be contributing to the compression neuropathy.

In questionable clinical scenarios, nerve conduction velocity and electromyography tests may be ordered to confirm the diagnosis of ATTS and the location of the DPN entrapment. Nerve conduction studies will show deep peroneal nerve distal latency, and EMG will demonstrate findings only in the EDB muscle belly.[rx]

If a soft tissue mass (ganglion or varicosities) are present on the physical exam, an MRI is an option. MR neurography is another imaging modality proven useful in diagnosing lower extremity entrapment neuropathies.[rx]

High-resolution musculoskeletal ultrasound imaging is also a recommendation as electrophysiologic studies are not always reliable due to variability in peripheral nerves.[rx]

Treatment of Anterior Tarsal Tunnel Syndrome

The treatment of ATTS is based on the underlying etiology. Treatment should begin with a trial of non-operative methods such as:

• Changes to footwear and shoe-lacing technique modification
• Biomechanical modifications such as over-the-counter orthotics, custom orthotics, or padding
• Topical anti-inflammatory or compound creams
• Oral or topical NSAIDs or neuropathic pain medications such as gabapentin
• Perineural corticosteroid/anesthetic injection at the site of nerve entrapment
• Compression socks to alleviate local edema or varicosities
• A period of decreased athletic activity or immobilization via CAM boot

Surgical options should only be presented after failing a period of non-operative treatment. Surgery is based on the underlying etiology and may include:

• Release or decompression of the extensor retinaculum and any surrounding scar tissue
• Excision of space-occupying lesions (ganglion, varicose veins)
• Resection of osteophytes (bone spurs)
• Neurolysis, nerve wrapping, resection of neuroma or neurectomy of the DPN

Surgery is most commonly performed via an open approach; however, minimally invasive endoscopic approaches are also viable options.[rx][rx][rx]

In each surgical case, the retinaculum must be identified, and the posterior tibial nerve visualized. One should avoid injuring branches of the nerve and carefully release the fibrous bands.

Differential Diagnosis

Differential diagnosis of ATTS includes other conditions which can cause distal paresthesias including[20]:

• Exertional anterior compartment syndrome
• Common peroneal nerve entrapment
• Superficial peroneal nerve entrapment
• 1st inter-space neuromas (Heuter’s neuroma)
• Lumbosacral radiculopathy
• Inflammatory disease states
• Primary nerve tumor
• Mid-foot retinaculum entrapment mimicking ATTS

Complications

Anterior tarsal tunnel syndrome that is left untreated can result in persistent pain or neuropathies of the deep peroneal nerve or its branches.

Surgical complications after decompression include nerve injury or extensor hallucis brevis wasting in the late-stage presentation.[rx] Additional postoperative risks include infection, wound dehiscence, scar tissue formation, failure to resolve pain/original symptoms, and the need for additional/revisional surgery.

References