Pulsatilla Nigricans; Uses, Dosage, Site Effects, Interactions

Pulsatilla Nigricans; Uses, Dosage, Site Effects, Interactions

Pulsatilla nigricans is used in the treatment of anxiety-related disorders. Though in clinical use for many years, the anxiolytic activity of Pulsatilla nigricans (Puls) has not been evaluated experimentally. Hence the present study was conducted in Swiss albino mice to evaluate the anxiolytic activity of Puls and compare its activity with the standard anxiolytic drug, diazepam. Homeopathic pathogenetic trials usually rely on symptom self-report measures. Adding objective biomarkers could enhance detection of subtle initial remedy effects. The present feasibility study examined electroencephalographic (EEG) effects of repeated olfactory administration of two polychrest remedies.

Pulsatilla, or pasque flower, is a strong, effective, and potentially toxic analgesic and sedative herb. It is included in this discussion because experienced herbalists and naturopathic physicians may recommend it for severe and intractable pain and insomnia. It is also used in the treatment of dysmenorrhea; in vitro, it has been shown to reduce uterine contractions. In dried form, this herb is expected to cause little harm when used in the proper dosage range; however, excessive (undefined amount) doses of the herb may cause severe gastritis, kidney, or urinary tract irritation. In its fresh form, pulsatilla can cause serious irritation and blistering of the oral, esophageal, and gut mucosa. Pulsatilla also may be adulterated by the presence of other more toxic species of Pulsatilla. Therefore, this herb should be restricted to use ONLY by those trained in its use, and familiar with its identification and contraindications. It is fully contraindicated during pregnancy and lactation. This herb is also contraindicated in depression, psychosis, and children. Its use with pharmaceutical analgesics is not recommended.

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Pulsatilla, which brings together 38 species of herbaceous perennial plants that colonize mainly Europe and Asia. Pulsatilla plants have medicinal properties. Recent biological and pharmacological research demonstrated that Pulsatilla species contain numerous compounds, including triterpenoid saponins, phytosterols and anthocyanins []. The pharmacological effects of these ingredients have not been studied extensively, but protoanemonin was found to exhibit antifungal and antibiotic properties.

Uses/ Indications of Pulsatilla Nigricans

  • Extracts of Pulsatilla have been used to treat reproductive problems such as premenstrual syndrome and epididymitis. Additional applications of plant extracts include uses as a sedative and for treating coughs. It is also used as an initial ingredient in homeopathic remedies.
  • Conditions of the male or female reproductive system.
  • Tension headaches.
  • Migraine headaches.
  • Hyperactive states.
  • Trouble sleeping (insomnia).
  • Boils.
  • Skin diseases.
  • Asthma and other lung diseases.
  • Earache.
  • Nerve problems.
  • General restlessness.
  • Digestive tract problems.
  • Urinary tract problems
  • Acne
  • Amenorrhoea
  • Anemia
  • Appetite, depraved
  • Blepharospasm
  • Breasts, pain behind
  • Bronchitis
  • Cold, Cough
  • Diarrhoea
  • Dysmenia
  • Epistaxis Eyes, lachrymal sac, inflammation of, granular ophthalmia
  • Gonorrhea, gout
  • Hemorrhoids
  • Heartburn
  • Hydrocele, congenital
  • Intermittent fever
  • Leucorrhoea
  • Menstruation, abnormal, vicarious
  • Neuralgia
  • Nymphomania
  • Ovaries, pain in, inflammation
  • Pregnancy, bladder trouble of, sickness of, heartburn of, diarrhoea
  • Rheumatism, gonorrheal

Dosage of Pulsatilla Nigricans

Ingredients: Pulsatilla 30c

  • Adult and children 2 years of age and older: Dissolve 5 pellets under the tongue 3 times a day until relieved or as directed by a doctor.


  • 2 pillules every 2 hours for the first 6 doses, then 4 times daily for up to 5 days or until symptoms improve. If symptoms worsen or persist consult a doctor.


Pulsatilla Nigricans


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