Magnesia Muriatica is also useful in stomach problems. Appetite is very poor and there is a bad taste in the mouth. Eructations are like rotten eggs. The patient cannot digest milk. Magnesia Muriatica also helps in liver problems when there is a pressing type of pain which is worse lying on right side. The liver is enlarged with bloating of the abdomen.
The next remedy of which I shall speak is the Chloride of Magnesia or Magnesia mur. This remedy acts particularly on women and children, especially in hysterical women and in scrofulous children.
It is indicated in women who suffer from hysterical paroxysms, with the following symptoms: After dinner, the patient is seized with nausea, trembling and fainting spells. These occur after dinner because that is the principal meal, and more is eaten then than at other times. The patient is anxious and restless and is always made worse from mental exertion. The headaches are described as congestive, with sensation as of boiling water in the cranium. The pains are referred to the temples and seem to be relieved by firm pressure with the hands. They are also better from wrapping the head up warmly. The patient also complains of a sensation as of a ball rising from the stomach into the throat. This is relieved by eructation. This shows that the accumulation of gas in the stomach is the cause of this reflex symptom. She also has bearing down in the uterine region and uterine spasms. The menses are black and pitch-like and are accompanied by pain in the back when walking, and in the thighs when sitting. She also has leucorrhoea after every stool or following the uterine spasms. In nearly all these cases in which Magnesia mur. is indicated, you will find characteristic constipation, in which the stools are passed with great difficulty, being composed of hard lumps, or they are so dry that they crumble as they pass the anus. If you find that symptom present with the uterine symptoms, you may be sure that Magnesia mur. will help the patient.
Indications of Magnesia Muriatica
- Bladder, paresis
- A headache.
- Heart, affections of.
- Liver, affections
- Menstruation, painful.
- Nocturnal emissions.
- Smell, disordered
- Spleen, enlarged
- Stomach, disorders of.
- Taste, disordered.
- Tinea ciliaris.
- Urine, straining to pass.
- Uterus, pain in, induration of.
- Water brash.
- A liver – remedy with pronounced characteristic constipation. Chronic liver affections with tenderness and pain, extending to spine and epigastrium, worse after food. Especially adapted to diseases of women, with a long history of indigestion and uterine disease; children who cannot digest milk. Evil effects of sea bathing.
- Head – Sensitive to noise; bursting headache; worse, motion, open air; better, pressure, and wrapping up warmly.Facial neuralgia pains, dull, aching, worse damp weather, slightest draft, better pressure heat.
- Nose – Nostrils ulcerated. Coryza. Nose stopped and fluent. LOSS OF SMELL AND TASTE, following catarrh. Cannot lie down. Must breathe through the mouth.
- Mouth – Blisters on lips. Gums swollen, bleed easily. Tongue feels burnt and scalded. Throat dry, with hoarseness.
- Stomach – Appetite poor, bad taste in the mouth. Eructations like rotten eggs. Continued rising of white froth into the mouth. Urine can be passed only by pressing abdominal muscles.
- Abdomen – Pressing pain in the liver; worse lying on right side. LIVER ENLARGED WITH BLOATING OF ABDOMEN; yellow tongue. Congenital scrotal hernia. Must use abdominal muscles to enable him to urinate.
- Urinary Organs – Urine difficult to void. The bladder can only be emptied by straining and pressure.
- Bowels – Constipation of infants during dentition; only passing small quantity; STOOLS KNOTTY, like sheep’s dung,
- Female – Menses black, clotted. Pain in back and thighs. Metrorrhagia; worse at night. Great excitement at every period. Leucorrhoea with every stool and after exercise. Tinea ciliaris, eruptions in face and forehead worse before menses.
- Heart – Palpitation and cardiac pain
- Respiratory – Spasmodic dry cough; worse forepart of night, with burning and sore chest.
- Extremities – Pain in back and hips; in arms and legs. Arms “go to sleep” when waking in the morning.
- Sleep – Sleep during the day; restless at night on account of heat and shock; anxious dreams.
Contra-Indications of Magnesia Muriatica
- Magnesia Muriatica must not be used unless it has been diluted with Ringer’s Injection prior to use.
- Use of Magnesia Muriatica is contraindicated in patients who are hypersensitive to procaine.
- As procaine is metabolized to produce para-aminobenzoic acid, it should be used with caution in patients who are allergic to para-aminobenzoic acid or its derivatives such as preservatives and sunscreens.
- Cross-sensitivity can occur between procaine and other local anesthetics of the para-aminobenzoic acid ester-type, para-aminobenzoic acid, and hydroxybenzoate preservatives.
- Procaine hydrochloride is contraindicated in patients with low plasma cholinesterase levels or who are receiving anticholinesterases; with myasthenia gravis, severe shock or impaired cardiac conduction; receiving sulfonamides.
The Dosage of Magnesia Muriatica
- Magnesia Muriatica concentrate must be diluted with Ringer’s Injection prior to use.
- Magnesia Muriatica concentrate or diluted solution must not be administered by intravenous injection. It is important to use sufficient Magnesia Muriatica solution to ensure that the myocardium is evenly cooled.
- The following information is intended as a guide only. Dosage may vary, depending on perfusion technique being used and the preference and experience of the surgeon. The volume of solution administered into the aortic root may vary depending on the duration or type of open-heart surgical procedure.
- Magnesia Muriatica must be diluted before use, at a ratio of 20 mL to 1 liter of Ringer’s Injection. The solution must be cooled to 4°C prior to use. Any unused portion should be discarded.
- Following institution of cardiopulmonary bypass and cross-clamping of the ascending aorta, the cold, diluted Magnesia Muriatica solution is administered by rapid infusion into the aortic root. The solution may be administered at a rate of about 300 mL/m2 body surface area/minute, over a period of about 2 to 4 minutes.
- External cardiac cooling helps to ensure that the heart remains continuously cold. This can be achieved by infusing a cold physiological solution into the pericardial sac. The warmed solution can be removed by suction and replaced by the cold solution to ensure maintenance of hypothermia.
- If myocardial electromechanical activity persists or recurs, administration of cold Magnesia Muriatica solution may be repeated at a rate of about 300 mL/m2/minute for a period of two minutes.
- Diluted Magnesia Muriatica solution may be readministered every 20 to 30 minutes, or sooner if the myocardial temperature reaches 15 to 20°C, or if a return of cardiac activity is observed.
- To reduce the microbiological hazard, the solution should be used as soon as practicable after preparation. This product is for use in one patient only. Discard any remaining contents.
Drug Interactions of Magnesia Muriatica
- When used as recommended systemic absorption of Magnesia Muriatica solution should not occur, and hence interactions between the Magnesia Muriatica solution and other medicines are unlikely. However, the following interactions could potentially occur if Magnesia Muriatica is absorbed systemically: Acetazolamide: Acetazolamide may inhibit hydrolysis of procaine; concurrent administration may therefore theoretically extend the plasma half-life of procaine.
- Anticholinesterase Agents – Anticholinesterase agents may inhibit procaine metabolism, leading to an increased risk of toxicity if procaine is used concurrently with anticholinesterase agents.
- Antimyasthenic Agents – Procaine may antagonise the effects of antimyasthenic agents on skeletal muscle; concurrent use may, therefore, result in worsening of myasthenia gravis symptoms. Temporary dosage adjustment of antimyasthenic agents may be required.
- CNS Depressant Medicines – Concurrent use of procaine with CNS depressant medicines may result in enhanced CNS depressant effects.
- Hyaluronidase – Hyaluronidase may increase the diffusion rate of procaine hydrochloride, resulting in a decreased time of onset, but an increase in systemic toxicity.
- Neuromuscular Blocking Agents – Concurrent administration of procaine and neuromuscular blocking agents may prolong or enhance neuromuscular blockade. Magnesium salts may also interact with neuromuscular blocking agents.
- Potassium-Containing or Potassium-Sparing Medicines- Potassium salts should be used sparingly, if at all, in patients receiving medicines which increase serum potassium concentrations. Examples include potassium-sparing diuretics, angiotensin converting enzyme (ACE) inhibitors, cyclosporin, and potassium-containing medicines. Hyperkalaemia is more likely to occur in patients with renal impairment.
- Sulfonamides – Concurrent administration of procaine with sulfonamides may reduce the antibacterial action of the sulfonamide.