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Naproxen Indications Contra Indications

Naproxen Indications/ Naproxen is an anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders

Indications of Naproxen For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout. Also for the relief of mild to moderate pain and the treatment of primary dysmenorrhea. Fibromyalgia Pain due to road traffic accident. A headache Severe fever Chest pain A migraine headache Acute pain due to trauma Rheumatoid arthritis Osteoarthritis Ankylosing spondylitis Accidental pain Acute abdominal pain due to gastritis/appendicitis Pain due to the especially musculoskeletal system Lumbago Low back pain PLID Polyarthralgia Muscles stiffness in nerve diseases Morning stiffness Multiple joint pain Muscles stiffness in the spinal cord Periarthritis of scapulohumeral For the management of primary dysmenorrhea.

Therapeutic Indications of Naproxen

Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Gout Suppressants
Naproxen and its salt are used to relieve postoperative pain (including that associated with dental surgery), postpartum pain, primary dysmenorrhea, pain following insertion of an intrauterine contraceptive device, orthopedic pain, headache (including a migraine), and visceral pain associated with cancer.
Naproxen sodium also may be used for self-medication to provide temporary relief of minor aches and pains associated with the common cold, headache, toothache, muscular aches, and backache.
Naproxen has been used in the symptomatic management of osteitis deformans (Paget’s disease of bone) and Bartter’s syndrome.
When used in the treatment of rheumatoid arthritis or juvenile rheumatoid arthritis, naproxen has relieved pain and stiffness, reduced swelling, and improved mobility and grip strength. In the treatment of osteoarthritis, naproxen has relieved pain and stiffness and improved knee joint function.
Naproxen appears to be the only palliative in these conditions and has not been shown to permanently arrest or reverse the underlying disease process. Naproxen sodium also may be used for self-medication to provide temporary relief of minor aches and pains associated with arthritis.
Naproxen and naproxen sodium are used for anti-inflammatory and analgesic effects in the symptomatic treatment of rheumatoid arthritis, osteoarthritis, juvenile rheumatoid arthritis, and ankylosing spondylitis.
Naproxen also is used in combination with lansoprazole for the symptomatic treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis in patients with a history of documented gastric ulcer who require continued use of an NSAIA.
Naproxen and naproxen sodium are used to relieve mild to moderately severe pain. Conventional (immediate-release) and delayed-release (enteric-coated) tablets and suspension formulations of naproxen or naproxen sodium are used for anti-inflammatory and analgesic effects in the symptomatic treatment of rheumatoid arthritis, osteoarthritis, juvenile rheumatoid arthritis, and ankylosing spondylitis.
Conventional (immediate-release) tablets and suspension formulations of naproxen or naproxen sodium also are used for the symptomatic treatment of tendinitis, bursitis, acute gout, pain, and primary dysmenorrhea. Suspension formulations of naproxen are preferred for the management of juvenile arthritis since this formulation provides maximum dosage flexibility. Because of the delayed-release properties of enteric-coated naproxen tablets, this formulation is not recommended for the management of acute pain.
Extended-release naproxen sodium tablets are used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, acute gout, mild to moderately severe pain, and primary dysmenorrhea. (Naproxen 250 mg is approximately equivalent to naproxen sodium 275 mg.) Naproxen sodium also may be used for self-medication for anti-inflammatory and analgesic effects to provide temporary relief of minor aches and pains, including those associated with arthritis, and of dysmenorrhea and for its antipyretic effect to reduce fever.
Naproxen has been used effectively to relieve pain, fever, redness, swelling, and tenderness in patients with acute gouty arthritis.
When used in patients with ankylosing spondylitis, naproxen has relieved night pain, morning stiffness, and pain at rest. In a limited number of controlled studies, the anti-inflammatory and analgesic effects of usual dosages of naproxen in the symptomatic treatment of ankylosing spondylitis were greater than those of placebo and comparable to those of usual dosages of aspirin or phenylbutazone (no longer commercially available in the US).

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Contra-Indications of Naproxen

Allergy to medicines called opioid antagonists (e.g. codeine, morphine);
Active peptic ulcer
Allergic to thiocolchicoside
Asthma
Pregnant
Urticaria
Concurrent peptic ulcer, or history of ulcer disease
Allergy to indomethacin, aspirin, or other NSAIDs
Patients with nasal polyps reacting with angioedema to other NSAIDs
Children under 2 years of age (with the exception of neonates with patent ductus arteriosus)
Some painkillers, including opioid painkillers;
Hypnotic drugs;
Psychotropic drugs;
Used monoamine oxidase inhibitors (MAOIs) such as phenelzine or tranylcypromine
Epilepsy;
Addiction or are recovering from addiction to another medication.
History of peptic ulcer disease,
Gastrointestinal bleeding,
Severe pre-existing renal and liver damage
Caution: pre-existing bone marrow damage (frequent blood cell counts are indicated)
Caution: bleeding tendencies of unknown origin
Caution: Parkinson’s disease, epilepsy, psychotic disorders
Patients who have a patent ductus arteriosus dependent heart defect (such as transposition of the great vessels)
Significant hypertension (high blood pressure)
Concomitant administration of lithium salts (such as lithium carbonate)
History of gastric bypass surgery
Renal impairment,Hepatic impairment.
Alcohol intolerance,
Renal impairment,
Cerebrovascular bleeding,
Heart failure,
Coagulation disorders,