Almotriptan; Uses, Dosage, Side Effects, Interactions

Almotriptan; Uses, Dosage, Side Effects, Interactions

Almotriptan is a sulfonamide triptan with extracerebral, intracranial vasoconstrictor activity. Almotriptan selectively binds to and activates serotonin 5-HT 1B and 1D receptors in the central nervous system (CNS), thereby causing extracerebral, intracranial blood vessel constriction. This may lead to pain relief from vascular headaches. Almotriptan may also relieve vascular headaches by preventing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve.

 

Almotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that cause pain, nausea, and other symptoms of a migraine. Almotriptan does not prevent migraine attacks.

Mechanism of action of Almotriptan

Almotriptan binds with high affinity to human 5-HT1B and 5-HT1D receptors leading to cranial blood vessel constriction. Almotriptan is a selective 5-hydroxytryptamine receptor subtype agonist indicated for the acute treatment of migraine attacks with or without aura in adults. Almotriptan is not intended for the prophylactic therapy of a migraine or for use in the management of a hemiplegic or a basilar migraine. Almotriptan is an agonist for a vascular 5-hydroxytryptamine receptor subtype (probably a member of the 5-HT1D family) having only a weak affinity for 5-HT1A, 5-HT5A, and 5-HT7 receptors and no significant affinity or pharmacological activity at 5-HT2, 5-HT3 or 5-HT4 receptor subtypes or at alpha1-, alpha2-, or beta-adrenergic, dopamine1,; dopamine2; muscarinic, or benzodiazepine receptors. This action in humans correlates with the relief of a migraine headache. In addition to causing vasoconstriction, experimental data from animal studies show that Almotriptan also activates 5-HT1 receptors on peripheral terminals of the trigeminal nerve innervating cranial blood vessels, which may also contribute to the antimigrainous effect of Almotriptan in humans.

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Indications of Almotriptan

  • Migraines

Contra-Indications of Almotriptan

Do not take almotriptan within 24 hours before or after using another migraine headache medicine

Dosage of Almotriptan

Strengths: 6.25 mg; 12.5 mg, 25 mg

A migraine

  • Initial dose: 6.25 mg or 12.5 mg orally as a single dose
  • Repeat dose: If a headache is relieved, but returns, may repeat with 1 dose orally provided there is a minimum interval of 2 hours between doses.
  • Maximum daily dose: 25 mg

A pediatric Migraine

Adolescents (12 to 17 years)

  • Initial dose: 6.25 mg or 12.5 mg orally as a single dose
  • Repeat dose: If a headache is relieved, but returns, may repeat 1 dose orally provided there is a minimum interval of 2 hours between doses.
  • Maximum daily dose: 25 mg

Side Effects of Almotriptan

The most common

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More common

Rare

Drug Interactions of Almotriptan

Almotriptan may interact with the following drug, supplements, & may change the efficacy of the drug

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Pregnancy Category of Almotriptan

FDA Pregnancy Category  C

Pregnancy

This medication should not be taken during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

It is not known if almotriptan passes into breast milk. If you are breastfeeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breastfeeding. The safety and effectiveness of using this medication have not been established for children less than 12 years of age. Its use by people in this age group is not recommended.

References

  1. Almotriptan

 

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